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Factors Influencing Response to One BoNT-A Injection Cycle in Subjects Suffering From Idiopathic Cervical Dystonia

Completed
Conditions
Idiopathic Cervical Dystonia
Registration Number
NCT00833196
Lead Sponsor
Ipsen
Brief Summary

A post marketing, international, multicenter, observational, prospective, longitudinal study. The purpose of the study is to describe cervical dystonia sub-types with their injection protocols and response to BoNT-A.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
404
Inclusion Criteria
  • Idiopathic cervical dystonia
  • TWSTRS severity score ≥ 15
  • At least a 12-week interval between the last injection (BoNT-A or BoNTB) and inclusion
  • Written informed consent prior to collect the data
Exclusion Criteria
  • Contraindications to any BoNT-A preparations
  • Secondary cervical dystonia
  • Subject already been included in the study

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Responder rate at peak effect following one BoNT-A injection cycle without any deviations from routine practiceAround 4 weeks post injection
Secondary Outcome Measures
NameTimeMethod
To describe subject and investigator's CGI scoresAround 4 weeks post injection
To describe TWSTRS change scores from inclusion (total score & subscales scores)Baseline, and around 4 weeks and 3 months post injection
To describe tremor change score from inclusion (TSUI scale)Baseline, and around 4 weeks and 3 months post injection
To describe the Cervical Dystonia Impact Profile (CDIP) 58 change from inclusionBaseline, and around 4 weeks post injection
To identify prognostic factors for response (Exploratory Objective)baseline, and around 4 weeks and 3 months post injection

Trial Locations

Locations (36)

Royal Prince Alfred Hospital

🇦🇺

Camperdown, Australia

St Vincent's Hospital

🇦🇺

Fitzroy, Australia

UZ Gent

🇧🇪

Gent, Belgium

Austin Hospital

🇦🇺

Heidelberg, Australia

Centre Hospitalier de Liège, Domaine Universitaire Sart Tilmen

🇧🇪

Liege, Belgium

Westmead Hospital

🇦🇺

Penrith, Australia

Alfred Hospital

🇦🇺

Prahran, Australia

AZ Sint Jan Brugge

🇧🇪

Brugge, Belgium

AZ Sint Augustinus Wilrijk

🇧🇪

Wilrijk, Belgium

Fakultní nemocnice U Sv.Anny

🇨🇿

Brno, Czechia

Fakultní nemocnice Olomouc

🇨🇿

Olomouc, Czechia

Krajská nemocnice Pardubice

🇨🇿

Pardubice, Czechia

Všeobecná fakultní nemocnice

🇨🇿

Praha, Czechia

Hôpital Neurologique et Neurochirurgical Pierre Wertheimer

🇫🇷

Bron, France

Hôpital Roger Salengro

🇫🇷

Lille, France

Hôpital La Timone

🇫🇷

Marseille, France

Hôpital La Pitié Salpétrière

🇫🇷

Paris, France

Hôpital Pasteur - CHU Nice

🇫🇷

Nice, France

Hôpital Haut Lévêque

🇫🇷

Pessac, France

Hôpital Purpan

🇫🇷

Toulouse, France

Praxis für Neurologie

🇩🇪

Neusaß, Germany

Praxis für Neurologie, International Neuroscience Institute

🇩🇪

Hannover, Germany

Praxis für Neurologie und Psychatrie

🇩🇪

Schorndorf, Germany

Hospital Santa Maria

🇵🇹

Lisboa, Portugal

Hospital General San Antonio - Centro Hospitalar do Porto

🇵🇹

Porto, Portugal

Tergooiziekenhuizen Hilversum

🇳🇱

Hilversum, Netherlands

Krankenhaus der Barmherzigen Brüder

🇩🇪

Trier, Germany

Martini Ziekenhuis Groningen

🇳🇱

Groningen, Netherlands

Serviço de Neurologia - Hospital de São João

🇵🇹

Porto, Portugal

16, ulitsa Vorovskogo

🇷🇺

Chelyabinsk, Russian Federation

12a, ulitsa Karbyisheva

🇷🇺

Kazan, Russian Federation

80, Volokolamskoye shossee

🇷🇺

Moscow, Russian Federation

6/8, ulitsa L'va Tolstogo

🇷🇺

St-Petersburg, Russian Federation

National Hospital for Neurology & Neurosurgery

🇬🇧

London, United Kingdom

Walton Centre for Neurology & Neurosurgery, Hope Hospital

🇬🇧

Manchester, United Kingdom

Royal Devon & Exeter Hospital

🇬🇧

Exeter, United Kingdom

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