To compare safety and effectiveness of combination of sacubitril and valsartan with telmisartan in patients suffering from heart failure.
- Conditions
- Health Condition 1: I509- Heart failure, unspecified
- Registration Number
- CTRI/2019/05/019284
- Lead Sponsor
- Dr Kunwar Shailen Dev Singh Guleria
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Patient of CHF with decreased ejection fraction
2. Adult patients of either sex, consenting for study
3. If no HF hospitalizations in prior year: BNP greater than or equal to 150 pg/mL
4. If a HF hospitalization in prior year: BNP greater than or equal to 100 pg/m
1. Unwilling patient.
2. Pregnant females.
3. Estimated glomerular filteration rate less than 30ml/min/1.73m2
4. Serum potassium greater than 5.2mmol/L
5. Symptomatic hypotensive patients
6. SBP less than 100mmHg at screening or less than 95mmHg at randomization
7.Patient with known history of angioedema
8. Patient on drugs that might interact with ARNI/ARBs
9. Patient with structural (valvular) heart disease.
10.Unacceptable side effects with ACE-inhibitors or ARBs
Study & Design
- Study Type
- PMS
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum BNP levelsTimepoint: After three months and six months of enrollment
- Secondary Outcome Measures
Name Time Method EchocardiogramTimepoint: After three months and six months of enrollment