The Effect of Intercostal Nerve Block With Dexamethasone and Ropivacaine on Rebound Pain After Thoracoscopic Surgery

Not Applicable

Not yet recruiting

• Conditions: Intercostal Nerve Block; Thoracoscopic Surgery; Rebound Pain; Dexamethasone
• Interventions: Drug: Dexamethasone 8mg+0.375% ropivacaine; Drug: 0.375% ropivacaine

• Registration Number: NCT05825378
• Lead Sponsor: Beijing Tiantan Hospital

Brief Summary

Regional nerve block is one of the commonly used methods for postoperative analgesia after thoracoscopic surgery. Recent studies have found that rebound pain may occur after regional block, which is defined as acute postoperative pain that occurs after the resolution of sensory block related to regional anesthesia, and seriously affects the quality of postoperative recovery of patients. There is evidence that rebound tenderness is associated with local anesthetic toxicity and proinflammatory effects. The aim of this study was to investigate the effect of dexamethasone on rebound pain after a single intercostal nerve block in patients undergoing thoracoscopic surgery.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-04
• Study First Submitted: 2023-04-11
• Study First Submitted QC: 2023-04-11
• Last Update Submitted: 2023-04-11
• Study First Posted: 2023-04-24
• Last Update Posted: 2023-04-24
• Study Start: 2023-05-01
• Primary Completion: 2025-05-05
• Study Completion: 2025-08-06

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 260

Inclusion Criteria

• Patients scheduled for elective thoracoscopic surgery Age > 18 years old ASA ⅰ-ⅲ Informed consent was signed

Exclusion Criteria

• Patients with aoagulation disorders Patients with allergy to local anesthetics Patients with severe cardiopulmonary diseases Patients had systemic steroid use Patients with chronic pain Patients with uncontrolled diabetes and mental disorders History of drug abuse; Body Mass Index more than 35 kg.m-2 Pregnant or breastfeeding woman.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group dexamethasone	Dexamethasone 8mg+0.375% ropivacaine	Dexamethasone 8mg+0.375% ropivacaine
group control	0.375% ropivacaine	0.375% ropivacaine

Primary Outcome Measures

Name	Time	Method
The incidence of rebound pain after the disappearance of nerve block effect	8 hours after the nerve block	NRS \< 3 in PACU and NRS \> 7 after the disappearance of nerve block effect

Trial Locations

Locations (1)

Beijing Tiantan Hospital, Capital Medical University; 🇨🇳 Beijing, China