Selective Extended Dissection in Different Types of Pancreatic Head Cancer: A Retrospective Cohort Study.

Completed

• Conditions: Carcinoma, Pancreatic Ductal
• Interventions: Procedure: Selective extended dissection of pancreaticoduodenectomy

• Registration Number: NCT05723978
• Lead Sponsor: Tianjin Medical University Cancer Institute and Hospital

Brief Summary

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with relatively poor survival. Surgery is the first choice for the treatment of patients with early pancreatic cancer. However, the surgical approach and the extent of resection for patients with pancreatic cancer are controversial at present.

The investigators optimized the procedure of standard pancreaticoduodenectomy to selective extended dissection (SED), which is based on the extra-pancreatic nerve plexus (PLX) potentially invaded by tumor. The investigators retrospectively analyzed the clinicopathological data of patients with pancreatic adenocarcinoma who underwent radical surgery in our center from 2011 to 2020. Patients who underwent standard dissection (SD) were matched 2:1 to those who underwent SED using propensity score matching (PSM). The log-rank test and cox regression model were used to analyze survival data. In addition, statistical analyses were performed for the perioperative complications, postoperative pathology and recurrence pattern.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01-01
• Primary Completion: 2022-07-01
• Study Completion: 2022-12-01
• Status Verified: 2023-01
• Study First Submitted: 2023-01-31
• Study First Submitted QC: 2023-02-09
• Last Update Submitted: 2023-02-09
• Study First Posted: 2023-02-13
• Last Update Posted: 2023-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 520

Inclusion Criteria

• 1. Patients diagnosed as resectable pancreatic cancer were pathologically diagnosed as PDAC after surgery.

2. Patients received radical surgery (R0) and had complete photos or videos of the operation.

Exclusion Criteria

• 1. The operation records as well as related photo or video data could not reflect the surgical approach and the extent of resection.

2. Patients with incomplete clinical, pathological, imaging and follow-up information.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Selective extended dissection (SED) group	Selective extended dissection of pancreaticoduodenectomy	-

Primary Outcome Measures

Name	Time	Method
Disease-free survival (DFS)	From the day the patient received surgery to the time the patient was diagnosed with postoperative recurrence, assessed up to 36 months.

Trial Locations

Locations (1)

Tianjin Medical University Cancer Institute and Hospital; 🇨🇳 Tianjin, Tianjin, China