Effects of Dietary Fibre on Glucose Metabolism and Satiety

Early Phase 1

Completed

• Conditions: Metabolic Syndrome; Obesity
• Interventions: Other: Reference; Other: Test meal; Other: No priming; Other: Priming

• Registration Number: NCT02093481
• Lead Sponsor: Lund University

Brief Summary

The experimental model is a semi-acute study where the purpose of the study is to evaluate food factors related to colonially derived regulation of glucose metabolism (and related parameters) and satiety in healthy subjects.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02
• Study First Submitted: 2014-03-10
• Study First Submitted QC: 2014-03-19
• Study First Posted: 2014-03-21
• Status Verified: 2014-06
• Primary Completion: 2014-06
• Study Completion: 2014-06
• Last Update Submitted: 2014-06-25
• Last Update Posted: 2014-06-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• Normal fasting blood glucose, BMI 19-25 kg/m2

Exclusion Criteria

• Gastrointestinal diseases or food allergies e.g. lactose-, gluten intolerance, metabolic disorders e.g. diabetes, tobacco/snuff users. Antibiotic or probiotic usage within two weeks, and during study. Vegetarians.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
- ind. CHO - prim	No priming	Reference: ate no indigestible carbohydrates the day prior to measurements of variables (no priming).
+ ind. CHO - prim	No priming	Test meal: ate intrinsic indigestible carbohydrates 1 day prior to measurements of variables (no priming)
- ind. CHO - prim	Reference	Reference: ate no indigestible carbohydrates the day prior to measurements of variables (no priming).
+ ind. CHO + prim	Test meal	Test meal: ate intrinsic indigestible carbohydrates 3 days prior to measurements of variables (priming)
+ ind. CHO + prim	Priming	Test meal: ate intrinsic indigestible carbohydrates 3 days prior to measurements of variables (priming)
- ind. CHO + prim	Priming	Reference:ate no intrinsic indigestible carbohydrates 3 days prior to measurements of variables (priming)
+ ind. CHO - prim	Test meal	Test meal: ate intrinsic indigestible carbohydrates 1 day prior to measurements of variables (no priming)
- ind. CHO + prim	Reference	Reference:ate no intrinsic indigestible carbohydrates 3 days prior to measurements of variables (priming)

Primary Outcome Measures

Name	Time	Method
Insulin	Postprandial 0-180 min after breakfast	The test products are both ingested one day and three days prior to measurements of variables.
Markers of colonic fermentation and inflammation	Postprandial 0-180 min after breakfast	The test products are both ingested one day and three days prior to measurements of variables.
Blood glucose	Postprandial 0-180 min after breakfast	The test products are both ingested one day and three days prior to measurements of variables.
Appetite hormones	Postprandial 0-180 min after breakfast	The test products are both ingested one day and three days prior to measurements of variables.

Secondary Outcome Measures

Name	Time	Method
Subjective satiety	Postprandial 0-180 min after breakfast	The measures of hunger, satiety, and desire to eat with the use of a VAS were determined every hour throughout the postprandial testing sessions.

Trial Locations

Locations (1)

Applied Nutrition and Food Chemistry, Lund Univeristy; 🇸🇪 Lund, SE, Sweden