Energetics in hypertrophic cardiomyopathy: translation between PET, MRI and cardiac myofilament function

Completed

Conditions: hypertrophy
thickening of the heart muscle
10028593

Registration Number: NL-OMON44786

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 56

Inclusion Criteria

HOCM-patients scheduled for classic myectomy and eligible for CMR-and PET imaging. Indication for myectomy was based on a significant LV outflow tract (LVOT) pressure gradient >=30 mmHg at rest or provoked as documented by echocardiography and symptoms, despite optimal medical treatment.
Aortic valve stenosis patients selected to undergo valve surgery, according to the ESC-guidelines on the management of valvular heart disease.
Non-hypertrophic carriers (NHC) eligible for CMR- and PET imaging;Ref. Vahanian A et al. Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology. Eur Heart J. 2007 Jan;28(2):230-68. ;Protocol page 11-12

Exclusion Criteria

Any absolute or relative contra-indication for CMR imaging (i.e. pacemaker and claustrophobia) or failure to give informed consent. Severely impaired renal function with a glomerular filtration rate (GFR) <30 ml/min.
Protocol page 11-12

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Correlation of energetic properties of the HOCM-heart (in vivo assessment with<br /><br>PET and MRI) with it*s in vitro (myofilamental) efficiency of contraction. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Comparison of energymetabolism (in vivo, in vitro) between HCM, aortic valve<br /><br>stenosis and non-hypertrophic carriers.<br /><br>- Histological determination of interstitial fibrosis and it*s relation to<br /><br>septal (regional) contraction using CMR tagging.<br /><br>- Peak strain values compared to contractile velocities of myofilaments.<br /><br>- Relation between existence of myocardial disarray and the extent of<br /><br>remodelling. </p><br>