Brain Health in Midlife (ADORE BRAIN)

Cardiometabolic markers of middle age women

时间窗: Baseline

Assess cardiometabolic marker values differences between the women diagnosed with a hypertensive disorder of pregnancy to the values of the healthy control.

Neurovascular hemodynamics of middle age women

时间窗: Baseline

Assess differences in heart rate via an ECG, and beat to beat blood pressure, cerebral blood flow, and pulse wave velocity) between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy control.

Brain structure & function of middle age women

时间窗: Baseline

Assess differences in MRI MPRAGE, fMRI and DTI sequencing scan between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy control.

Alzheimer's disease-related plasma biomarkers of middle age women

时间窗: Baseline

Assess value differences in a predetermined Alzheimer's disease-related plasma biomarkers between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy controls.

Cardiometabolic Biomarkers - Glucose & Lipids

时间窗: Baseline

Assess differences in cardiometabolic biomarkers between the women diagnosed with a hypertensive disorder of pregnancy and healthy control.

Cardiometabolic Biomarkers - Insulin

时间窗: Baseline

Assess cardiometabolic marker values differences between the women diagnosed with a hypertensive disorder of pregnancy to the values of the healthy control.

Cardiometabolic Biomarkers - Hemoglobin A1C

时间窗: Baseline

Assess cardiometabolic marker values differences between the women diagnosed with a hypertensive disorder of pregnancy to the values of the healthy control.

Neurovascular Hemodynamics - Heart Rate

时间窗: Baseline

Assess differences in heart rate, mean arterial pressure, cerebral blood flow, and pulse wave velocity between the women diagnosed with a hypertensive disorder of pregnancy and healthy control. Heart rate was measured using a 5-lead electrocardiogram.

Neurovascular Hemodynamics - Mean Arterial Pressure

时间窗: Baseline

Assess differences in heart rate, mean arterial pressure, cerebral blood flow, and pulse wave velocity between the women diagnosed with a hypertensive disorder of pregnancy and healthy control. Mean arterial pressure was measured with each heart beat using a specialized cuff placed on the finger.

Neurovascular Hemodynamics - Cerebral Blood Flow

时间窗: Baseline

Assess differences in heart rate, mean arterial pressure, cerebral blood flow, and pulse wave velocity between the women diagnosed with a hypertensive disorder of pregnancy and healthy control. Cerebral blood flow, the velocity at which blood travels through the middle cerebral artery, was measured using transcranial doppler ultrasound.

Neurovascular Hemodynamics - Pulse Wave Velocity

时间窗: Baseline

Assess differences in heart rate, mean arterial pressure, cerebral blood flow, and pulse wave velocity between the women diagnosed with a hypertensive disorder of pregnancy and healthy control. Pulse wave velocity is an indicator of vessel stiffness and was measured using a specialized blood pressure cuff placed on the upper thigh.

Brain Structure

时间窗: Baseline

Assess differences in brain structure between women diagnosed with a hypertensive disorder of pregnancy and healthy controls using fMRI. A T1-weighted structural scan was completed (3D MPRAGE sequence). Structural data was segmented using FreeSurfer to quantify brain volumes. Volumes are reported in cubic millimeters (mm\^3).

Brain Functional Connectivity

时间窗: Baseline

Assess differences in brain functional connectivity between women diagnosed with a hypertensive disorder of pregnancy and healthy controls using fMRI. A resting state scan run of gradient echo blood oxygen level dependent (BOLD) scans was completed. Resting state data was processed using analysis protocols that explored functional neural networks (i.e., default mode network (DMN), attention network, salience network). Functional connectivity is reported as Fisher z-transformed correlation coefficients derived from fMRI data.

Alzheimer's Disease-related Biomarkers

时间窗: Baseline

Assess differences in Alzheimer's disease-related biomarkers between the women diagnosed with a hypertensive disorder of pregnancy and healthy control.