Brain Health in Midlife

• Conditions: Dementia; Brain Health; Gestational Hypertension; Alzheimer Disease; Cardiovascular Diseases; Pregnancy Related; Pre-Eclampsia

• Registration Number: NCT06640842
• Lead Sponsor: University of Kansas Medical Center

Brief Summary

The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-08
• Study First Submitted: 2024-08-29
• Study Start: 2024-09-23
• Study First Submitted QC: 2024-10-11
• Last Update Submitted: 2024-10-11
• Study First Posted: 2024-10-14
• Last Update Posted: 2024-10-14
• Primary Completion: 2025-06
• Study Completion: 2025-06

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

• Participated in the ADORE trial ( R01 HD083292)

Exclusion Criteria

• History of seizures or Epilepsy
• Pregnant at screening
• Ineligible to complete MRI due to metal in the body

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiometabolic markers of middle age women	Baseline	Assess cardiometabolic marker values differences between the women diagnosed with a hypertensive disorder of pregnancy to the values of the healthy control.
Neurovascular hemodynamics of middle age women	Baseline	Assess differences in heart rate via an ECG, and beat to beat blood pressure, cerebral blood flow, and pulse wave velocity) between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy control.
Brain structure & function of middle age women	Baseline	Assess differences in MRI MPRAGE, fMRI and DTI sequencing scan between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy control.
Alzheimer's disease-related plasma biomarkers of middle age women	Baseline	Assess value differences in a predetermined Alzheimer's disease-related plasma biomarkers between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy controls.

Trial Locations

Locations (1)

The University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States