Comparative Evaluation Of Efficacy Of Demineralised Bone Matrix With Resorbable Collagen Membrane And Platelet Rich Fibrin After Extraction Of Mandibular Molar For Socket Preservation.
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Compare and Evaluate of Efficacy of Demineralised Bone
研究概览
简要总结
This study includes patients (18–60 years) undergoing mandibular molar extraction at the Oral and Maxillofacial Surgery Department. After obtaining informed consent and basic blood investigations (CBC), patients will be randomly assigned to two groups:
- Group A: Socket preservation using Demineralised Dentin Matrix (Osseograft) with a Resorbable Collagen Membrane.
- Group B: Socket preservation using Platelet-Rich Fibrin (PRF) prepared from autologous blood by centrifugation at 3000 rpm for 10 minutes.
Each group will be further divided into subgroups based on age (18–39 and 40–60). All extractions will be performed under local anesthesia using standard aseptic protocols by a single operator. After placement of materials, resorbable sutures will be placed.
Patients will receive standard post-extraction medications (Amoxicillin 500 mg and Diclopara TDS for 5 days). CBCT scans will be taken before extraction and at 4 months post-operatively. Healing will be evaluated at 7 days and 4 months post-op.
Parameters assessed include:
- Alveolar bone height and width (using CBCT measurements),
- Bone density via gray scale values (DICOM viewer),
- Clinical healing (pain, swelling, infection),
- Comparison of socket healing between materials.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Day(s) 至 60.00 Day(s)(—)
- 性别
- All
入选标准
- •Individual Falling In 18-39 years And 40-60 years Age Groups 2) Individual In Need of Mandibular Molar Extraction.
- •Healthy Individual Without Any Co- Morbidity.
排除标准
- •Individuals With Known H/O Of Thyroid Disorder, Renal Disease, Diabetes Mellitus, Uncontrolled Hypertension, Under Antiplatelets & Anticoagulant Therapy, Bronchial Asthma.
- •Pregnant Females.
结局指标
主要结局
Compare and Evaluate of Efficacy of Demineralised Bone
时间窗: 4 months
Matrix with Resorbable Collagen Membrane and Platelet Rich
时间窗: 4 months
Fibrin for Preservation of Alveolar Socket after Extracti on of
时间窗: 4 months
Mandibular Molars.
时间窗: 4 months
次要结局
未报告次要终点
研究者
kshitija dhoke
Nair hospital dental college
