Office, Home, and Ambulatory Blood Pressure Measurements in Pediatric Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Elevated Blood Pressure
- Sponsor
- Children's Hospital Medical Center, Cincinnati
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Determine blood pressure phenotype
- Status
- Active, not recruiting
- Last Updated
- 10 months ago
Overview
Brief Summary
This will be a prospective observational study. The population would be pediatric patients 6 years to <19 years of age who were referred for elevated blood pressure to investigate if home blood pressure (HBP) can determine blood pressure phenotype (normotensive, hypertensive, masked hypertension, white coat hypertension) as accurately as ambulatory blood pressure monitor (ABPM) in childhood and adolescence.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 6 years to \<19 years old;
- •Elevated blood pressure defined as 15% lower than the 95%ile BP based on clinical practice guidelines(CPG) but less than stage II hypertension based on CPG;
- •Tolerate ABPM 24 hours;
- •Tolerate HBP; and
- •Can have diabetes mellitus, obstructive sleep apnea, and attention deficit hyperactivity disorder managed by medication.
- •On stable doses of medications known to affect BP such as:
- •Corticosteroids
- •Calcineurin inhibitors
- •Oral decongestants;
- •Clinically stable
Exclusion Criteria
- •On antihypertension medications or treated in the last 6 months;
- •Structural heart disease such as:
- •Obstructive valvular disease
- •Coarctation of the aorta
- •Cardiomyopathy;
- •Other secondary causes such as:
- •Renal artery stenosis
- •Neurological condition with dysautonomia;
- •Recent initiation of medications known to affect BP such as:
- •Corticosteroids
Outcomes
Primary Outcomes
Determine blood pressure phenotype
Time Frame: 6-12 months after enrollment
The primary objective of this study is to investigate if home blood pressure (HBP) can determine blood pressure phenotype (normotensive, hypertensive, masked hypertension, white coat hypertension) as accurately as ambulatory blood pressure monitor (ABPM) in childhood and adolescence.
Secondary Outcomes
- HBP correlation with end organ damage(6-12 months after enrollment)