NCT00259662已完成不适用
High-dose Statin Therapy in the Perioperative Period and DVT Prevention.
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 2
- 主要终点
- Decrease in incidence of deep vein thrombosis
研究概览
简要总结
This study is designed to determine if the use of atorvastatin (Lipitor), a member of the HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory responses and deep vein thrombosis formation when given in high doses in the perioperative period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •gynecologic tumor scheduled for resection
排除标准
- •prior reaction to statins
- •renal insufficiency
- •liver disease
- •h/o alcoholism
- •prior h/o DVT or hypercoagulability
- •concurrent medications that significantly affect cytochrome P450 3A4
- •breast feeding or pregnancy
结局指标
主要结局
Decrease in incidence of deep vein thrombosis
次要结局
- Decrease in inflammatory mediator release.
研究者
研究点 (2)
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