The efficacy of parecoxib combined with paracetamol for reducing opioid consumption after breast cancer surgery: A prospective randomized controlled trial
Phase 2
Completed
- Conditions
- The efficacy of intra-operative parecoxib with paracetamol for reducing opioid consumption in patient undergoing breast cancer surgery under general anesthesiabreast cancer surgery, parecoxib, paracetamol
- Registration Number
- TCTR20230301004
- Lead Sponsor
- FACULTY OF MEDICINE RESEARCH GRANT KHON KAEN UNIVERSITY
- Brief Summary
A perioperative combination of intravenous Parecoxib and Paracetamol significantly reduced postoperative morphine consumption during 24 hours and improved the quality of life postoperatively, although without statistically significance
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 60
Inclusion Criteria
female age 18-65 year
ASA classification 1-3
Patients scheduled for elective breast surgery under general anesthesia at operating room, Srinagarind hospital
Exclusion Criteria
Patients with hypersensitivity or contraindication to the study drugs.
allergy for sulfamethoxazole
History of opioid or steroid (Dexamethasone,Hydrocortisone) used.
Pregnancy
Psychologic problems
Operation change
Refuse to participate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative opioid consumption 24 hours measure opioid consumption (mg)
- Secondary Outcome Measures
Name Time Method Post operative pain score 24 hour, 3 month numeric rating scale 0-10,assess quality of life during postoperatively 24 hour WHOQOL-BREF-THAI,side effect of opioid (Nausea and vomiting episode, ambulation, sedation score, RS depression) 24 hour grading score