Effect of Increased Muscular Work During Different Weaning Strategies in Critically Ill Patients
试验速览
- 阶段
- 不适用
- 发起方
- 试验地点
- 2
- 主要终点
- 1. Days of intubation 2. Days of mechanical ventilation
研究概览
简要总结
Most patients admitted to intensive care units require mechanical ventilation. Weaning from assisted/controlled ventilation begins when we recognize that the patient has recovered adeguately from acute respiratory failure.
If weaning is delayed, costs are increased, as are the risks of nosocomial pneumonia, cardiac-associated morbility, and death. On the other hand, weaning too soon often results in reintubation, which is associated with complications similar to those of prolonged ventilation.
The aim of this trial is to establish an evidence-based approach to weaning and to determine when a patient is ready to be weaned from mechanical ventilation, and what is the best weaning technique.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age higher than 18 yrs
- •PaO2/FiO2 greater or equal than 150 with PEEP equal or lower than 10, and minute ventilation lower than 15 l/min
- •Temperature lower than 38,5°C
- •Stable hemodynamics: HR 60-125 b/min, SBP 90-160 mmHg without or with dopamine lower than 10 gamma/Kg/min or dobutamine lower than 10 gamma/Kg/min, no acute arrythmias
- •Hb higher than 8 g/dl
- •GCS higher or equal than 9
- •The attending physician has to agree that the patient is in stable conditions and ready to be weaned from the ventilator
排除标准
- •presence of chronic neuromuscular diseases
- •need of surgical intervention within the next 72 hours
- •difficult tracheal intubation
- •tracheostomized patients
结局指标
主要结局
1. Days of intubation 2. Days of mechanical ventilation
时间窗: 28 days
次要结局
- 1. The day of eventual tracheostomy 2. Organ Failure 3. The mortality at 28° day 4. Outcome at 6 months(1 year)