NCT02052804已完成不适用
Understanding and Treating Heart Failure With Preserved Ejection Fraction: Novel Mechanisms, Diagnostics and Potential Therapeutics
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 700
- 试验地点
- 2
- 主要终点
- Percent of patients meeting new diagnostic criteria for HFpEF
研究概览
简要总结
The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate the clinical, cellular and molecular mechanisms involved with the development and progression of HFpEF; 4) to design and test new therapeutic strategies for patients with HFpEF.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Group 1 No clinically overt heart failure
- •Group 2 Known coronary artery disease
- •Group 3 Known heart failure with preserved ejection fraction
- •Group 4 Known heart failure with reduced ejection fraction
- •Group 5 Healthy age-matched controls
排除标准
- •Age <18 years
- •Known malignancy with expected survival <1 year
- •Pregnant or recent pregnancy <6 months
- •Recent event (<2 weeks since Acute Coronary Syndrome, Heart failure or other admission
- •Severe mitral or aortic stenosis
结局指标
主要结局
Percent of patients meeting new diagnostic criteria for HFpEF
时间窗: Up to 5 years
次要结局
未报告次要终点
研究者
Justin Ezekowitz
Associate Professor, University of Alberta; Director, Heart Function Clinic- Mazankowski Alberta Heart Institute
University of Alberta
研究点 (2)
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