NCT02052804CompletedNot Applicable
Understanding and Treating Heart Failure With Preserved Ejection Fraction: Novel Mechanisms, Diagnostics and Potential Therapeutics
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Alberta
- Enrollment
- 700
- Locations
- 2
- Primary Endpoint
- Percent of patients meeting new diagnostic criteria for HFpEF
Study Overview
Brief Summary
The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate the clinical, cellular and molecular mechanisms involved with the development and progression of HFpEF; 4) to design and test new therapeutic strategies for patients with HFpEF.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Group 1 No clinically overt heart failure
- •Group 2 Known coronary artery disease
- •Group 3 Known heart failure with preserved ejection fraction
- •Group 4 Known heart failure with reduced ejection fraction
- •Group 5 Healthy age-matched controls
Exclusion Criteria
- •Age <18 years
- •Known malignancy with expected survival <1 year
- •Pregnant or recent pregnancy <6 months
- •Recent event (<2 weeks since Acute Coronary Syndrome, Heart failure or other admission
- •Severe mitral or aortic stenosis
Outcomes
Primary Outcomes
Percent of patients meeting new diagnostic criteria for HFpEF
Time Frame: Up to 5 years
Secondary Outcomes
No secondary outcomes reported
Investigators
Justin Ezekowitz
Associate Professor, University of Alberta; Director, Heart Function Clinic- Mazankowski Alberta Heart Institute
University of Alberta
Study Sites (2)
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