Understanding and Treating Heart Failure With Preserved Ejection Fraction: Novel Mechanisms, Diagnostics and Potential Therapeutics
Completed
- Conditions
- Heart Failure
- Registration Number
- NCT02052804
- Lead Sponsor
- University of Alberta
- Brief Summary
The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate the clinical, cellular and molecular mechanisms involved with the development and progression of HFpEF; 4) to design and test new therapeutic strategies for patients with HFpEF.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 700
Inclusion Criteria
- Group 1 No clinically overt heart failure
- Group 2 Known coronary artery disease
- Group 3 Known heart failure with preserved ejection fraction
- Group 4 Known heart failure with reduced ejection fraction
- Group 5 Healthy age-matched controls
Exclusion Criteria
- Age <18 years
- Known malignancy with expected survival <1 year
- Pregnant or recent pregnancy <6 months
- Recent event (<2 weeks since Acute Coronary Syndrome, Heart failure or other admission
- Severe mitral or aortic stenosis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percent of patients meeting new diagnostic criteria for HFpEF Up to 5 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
University of Alberta
🇨🇦Edmonton, Alberta, Canada
University of Calgary
🇨🇦Calgary, Alberta, Canada