Evaluation of the Cell Detachment Ratio on pH-responsive Chitosan as a Prognostic Factor in Lung Cancer

• Conditions: Early Detection of Cancer; Clinical Decision-Making

• Registration Number: NCT04218188
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Biomaterial-based cell culture models have been gaining increasing attention as potential therapeutic strategies. The purpose of this project is to evaluate whether the cell detachment ratio on pH-responsive chitosan could be correlated with the overall survival in lung cancer patients. Through controllable cell-material interaction, this project has the intention to develop an alternative tool for both early diagnosis and accurate prognosis in cancer therapeutics.

Detailed Description

Not available

Study Timeline

• Status Verified: 2019-12
• Study First Submitted: 2019-12-17
• Study First Submitted QC: 2020-01-02
• Study Start: 2020-01-05
• Study First Posted: 2020-01-06
• Last Update Submitted: 2020-01-12
• Last Update Posted: 2020-01-14
• Primary Completion: 2020-11-17
• Study Completion: 2022-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Lung cancer patient between 20-70 years old who need surgery for the resection of lung lesions.
• Willing to sign the consent form under the informed consent.

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Exclusion Criteria

• Vulnerable subjects included minors, prisoners, aborigines, pregnant women, people with mental disorders, students, and subordinates, etc.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The correlation between the cell detachment ratio and the overall survival	5-year follow-up after tumor resection	The purpose of this project is to evaluate whether the cell detachment ratio on pH-responsive chitosan could be correlated with the overall survival in lung cancer patients, hence serve as a prognostic factor for therapeutic strategies. The patient's information required for meta-analysis will be retrieved from medical records, and the log-term follow-up will be conducted.

Secondary Outcome Measures

Name	Time	Method
The analyses of the detached cells by specific markers	About one week	The isolated and purified patient-derived tumor cells will be characterized by the expression of surface markers using flow cytometry.

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan