A pharmacokinetic study of pyridoxal-5*-phosphate and pyrixodine

Completed

• Conditions: onderzoek naar opname en omzetting van pyridoxal-5'-fosfaat (farmacokinetiek); Uptake and metabolism of different forms of vitamin B6

• Registration Number: NL-OMON45563
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

healthy, adults, both male and female, aged between 20 and 50 years with normal liver and kidney function, with normal BMI (between 19 and 25), and able to come to the research laboratory on 3 specified occasions within a one week period

Exclusion Criteria

use of medication (with the exception of oral contraceptives), use of vitamin supplements during the past 6 months, detectable plasma level of pyridoxine, non-normal liver and kidney functions, BMI <19 or >25, alcohol consumption > 2 drinks/day,

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Using LC-MS-QTOF plasma concentrations of pyridoxine (PN) will be measured</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Plasma concentrations of other B6 vitamers and metabolites: pyridoxal (PL),<br /><br>pyridoxamine (PM), and the phosphorylated derivative pyridoxal 5*- phosphate<br /><br>(PLP) and 4-Pyridoxinic acid (PA).</p><br>