NCT07128368尚未招募不适用
Mechanisms of Resistance Exercise Training for Improved Muscle Insulin Sensitivity
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- Mayo Clinic
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Change in muscle protein synthesis
研究概览
简要总结
To uncover the underlying mechanisms of resistance exercise training benefits on glucose metabolism and insulin sensitivity in muscle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sedentary (≤30min of physical activity on ≤1 day/week)
- •Weight stable for ≥3 months prior to study
排除标准
- •Active coronary artery disease or heart failure.
- •Participation in a structured exercise program > 1 day/week.
- •A known medical condition that in the judgment of the investigator might interfere with the completion of the protocol such as the following examples:
- •Abnormal liver function test results (Transaminase >2 times the upper limit of normal)
- •Abnormal renal function test results (calculated GFR <60 mL/min/1.73m2); If on antihypertensive, thyroid, anti-depressant or lipid lowering medication, lack of stability on the medication for the past 2 months prior to enrollment in the study
- •Uncontrolled thyroid disease (TSH undetectable or >10 mlU/L); testing required within three months prior to admission for subjects with a goiter, positive antibodies, or who are on thyroid hormone replacement, and within one year otherwise
- •Abuse of alcohol or recreational drugs
- •Active tobacco usage
- •Infectious process not anticipated to resolve prior to study procedures (e.g. meningitis, pneumonia, osteomyelitis).
- •Uncontrolled arterial hypertension (Resting diastolic blood pressure >90 mmHg and/or systolic blood pressure >160 mmHg) at the time of screening.
- •A recent injury to body or limb, muscular disorder, use of any medication, any carcinogenic disease, or other significant medical disorder if that injury, medication or disease in the judgment of the investigator will affect the completion of the protocol
- •Active pregnancy
- •Menopause (defined as absence of menstruation for 12 consecutive months)
- •Restrictions on Use of Other Drugs or Treatments:
- •Any other medication believed to be a contraindication to the subject's participation.
研究组 & 干预措施
Resistance Exercise Training
Experimental
干预措施: Resistance Exercise Training (Other)
结局指标
主要结局
Change in muscle protein synthesis
时间窗: Baseline; 8 weeks
Rate of insulin-stimulated synthesis of individual proteins
次要结局
未报告次要终点
研究者
Mark Pataky
Associate Consultant I Endocrinology, Diabetes and Metabolism
Mayo Clinic
研究点 (1)
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