Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Parameter θ of dynamic fluidity of brain activity
研究概览
简要总结
Lewy body disease (LBD) is a neurodegenerative disorder that causes cognitive and behavioral problems. However, it is difficult to diagnose, and its pathophysiology is still not fully understood. The usual diagnostic criteria for LBD have excellent specificity but poor sensitivity. In particular, we lack paraclinical tests that can make a significant contribution. LBD patients may exhibit abnormalities in brain activity dynamics, which can be detected by EEG and may be linked to neuronal dysfunctions specific to the disease. The objective of this study is twofold: first, to assess the validity of this observation, that is, to confirm that the observed phenomenon is indeed linked to the pathophysiology of LBD, and second, to clarify the nature of these abnormalities by exploring the brain dynamics of LBD patients in greater detail.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult subjects (≥18 years old).
- •Subject who participated in the Alpha-Lewy-MA cohort and underwent RT-QuIC analysis.
- •Subject who underwent a standard EEG examination at HUS between January 1, 2012, and January 1, 2020.
排除标准
- •- Subject who expressed opposition to participating in the study.
结局指标
主要结局
Parameter θ of dynamic fluidity of brain activity
时间窗: Up to 12 months
Parameter θ of dynamic fluidity of brain activity (quantifying the system's ability to move away from its current configuration) θ is used to measure something specific in the brain: how flexible its activity is. Quantifying the system's ability to move away from its current configuration: * In plain words, θ tells us how much the brain can change from its current state. * High θ → brain is very flexible, can switch between states easily. * Low θ → brain is rigid, stays in the same pattern longer.
次要结局
未报告次要终点