A Phase II Pilot Study of Stereotactic Radiosurgery for Limited Malignant Melanoma Brain Metastases

SWOG Cancer Research Network86 sites in 1 country2 target enrollmentJuly 1999

ConditionsMelanoma (Skin)Metastatic Cancer

Overview

Phase: Phase 2
Intervention: Not specified
Conditions: Melanoma (Skin)
Sponsor: SWOG Cancer Research Network
Enrollment: 2
Locations: 86
Status: Terminated
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Stereotactic radiosurgery may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of radiation therapy followed by stereotactic radiosurgery in treating patients who have brain metastases from malignant melanoma.

Detailed Description

OBJECTIVES: I. Estimate the 6 month intracranial progression rate and 6 month overall survival rate in patients with limited brain metastases from malignant melanoma undergoing whole brain radiotherapy followed by stereotactic radiosurgery boost. II. Evaluate the qualitative and quantitative toxic effects of this regimen in these patients. OUTLINE: Patients undergo whole brain radiotherapy 5 days a week for 3 weeks, followed 3-5 weeks later by stereotactic radiosurgery. Patients are followed every 3 months until death. PROJECTED ACCRUAL: A total of 60 patients will be accrued for this study within 2 years.

Registry

clinicaltrials.gov

Start Date

July 1999

End Date

August 2007

Last Updated

13 years ago

Study Type

Interventional

Study Design

Single Group