Serum Copeptin as a Predictor of the Risk of Hyponatremia After Transurethral Prostatectomy

Completed

• Conditions: Benign Prostatic Hyperplasia
• Interventions: Diagnostic Test: serum copeptin

• Registration Number: NCT03912766
• Lead Sponsor: Medical University of Lodz

Brief Summary

Hyponatremic hypovolemia is a frequent complication of transurethral resection of the prostate gland (TURP). Copeptin has been established as is a surrogate marker of vasopressin and is measured useful for thea clinical assessment of various sodium and water disturbances. The aim of our the study was to assess the utility of serum concentration of copeptin (CPP) and brain natriuretic peptide (NT-proBNP) for the prediction of postoperative alterations of serum sodium concentration. Study population comprised 43 patients with benign prostatic hyperplasia (BPH) undergoing transurethral resection of the prostate gland. In a forward stepwise multiple regression only serum copeptin before the surgery and the duration of TURP significantly explained the variation of sodium concentration for 12 hours from the start of the surgery. Serum NT-proBNP before the surgery did not predict hyponatremia 12 hours after TURP.Conclusion Serum copeptin before TURP surgery but not NT-proBNP may be a clinically useful marker of a decrease of serum sodium after TURP surgery.

Detailed Description

Introduction.Hyponatremic hypovolemia is a frequent complication of transurethral resection of the prostate gland (TURP). Copeptin has been established as is a surrogate marker of vasopressin and is measured useful for thea clinical assessment of various sodium and water disturbances. The aim of our the study was to assess the utility of serum concentration of copeptin (CPP) and brain natriuretic peptide (NT-proBNP) for the prediction of postoperative alterations of serum sodium concentration.

Methods. Study population comprised 43 patients with benign prostatic hyperplasia (BPH) undergoing transurethral resection of the prostate gland (TURP) Serum sodium and copeptin (CPP) were measured before the procedure and 12 hours after its completion. and sSerum NT-proBNP was assessment at baseline. Total amount of fluids and sodium administered intravenously and to flush the bladder during TURP was calculated in each patient. Receiver operator characteristics (ROC) curve analysis was used to determine the value of of copeptin (CPP) and NT-proBNP for that could prediction of the decrease of serum sodium after TURP

Study Timeline

• Study Start: 2016-02-01
• Primary Completion: 2017-01-02
• Study Completion: 2018-03-30
• Status Verified: 2019-04
• Study First Submitted: 2019-04-05
• Study First Submitted QC: 2019-04-10
• Last Update Submitted: 2019-04-10
• Study First Posted: 2019-04-11
• Last Update Posted: 2019-04-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 43

Inclusion Criteria

• glomerular filtration rate estimated from serum creatinine with CKD-EPI formula (eGFR) >45 ml/min.

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Exclusion Criteria

• acute infection
• heart failure (NYHA stage 3 or 4)
• diabetes insipidus
• nephrogenic diabetes insipidus
• other sodium homeostasis abnormalities
• impaired consciousness
• psychogenic polydipsia
• alcohol abuse.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Transurethral Prostatectomy	serum copeptin	male patients undergoing transurethral prostatectomy (TURP) for benign prostatic hyperplasia, routine surgical removal using resectoscope

Primary Outcome Measures

Name	Time	Method
change of serum sodium after surgery	change of serum sodium from baseline to 12 hours post surgery	predictive value of serum copeptin measured before surgery for serum sodium change after the surgery

Trial Locations

Locations (1)

Department of Nephrology, Hypertension and Kidney Transplantation; 🇵🇱 Łódź, Poland