NCT03663634CompletedNot Applicable
Cytochalasin B Supplementation to ICSI Handling Medium
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Ibn Sina Hospital
- Enrollment
- 987
- Locations
- 1
- Primary Endpoint
- oocyte survival rate
Study Overview
Brief Summary
Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Cytochalasin B serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Cytochalasin B during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •All ICSI candidates patients
Exclusion Criteria
- •No exclusion
Arms & Interventions
Handling Medium Supplemented with Cytochalasin B
Experimental
Intervention: Cytochalasin B use in ICSI handling medium (Other)
Handling Medium as it is.
No Intervention
Outcomes
Primary Outcomes
oocyte survival rate
Time Frame: 6 days of culture
number of survived oocyte after intracytoplasmic sperm injection
Secondary Outcomes
- fertilization rate(6 days of culture)
- clinical pregnancy rate(three months)
- ongoing pregnancy rate(four months)
- blastocyst formation rate(6 days of culture)
- embryo utilization rate(6 days of culture)
Investigators
Muhammad Fawzy
IVF Lab Director
Ibn Sina Hospital
Study Sites (1)
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