A Cohort Study of Environmental Endocrine Disrupting Chemicals and Female Reproductive Health
- Conditions
- IVF
- Registration Number
- NCT05373290
- Lead Sponsor
- Peking University People's Hospital
- Brief Summary
Infertility is a disease that seriously affects the physical and mental health of women of childbearing age. The incidence of infertility has been increasing in recent years. Studies have shown that the occurrence of infertility may be related to environmental endocrine disrupting substances. This project was designed to establish a cohort study on environmental endocrine disrupting substances and in vitro fertilization (IVF) treatment, collect blood, urine, semen, follicular fluid, granulosa cells, chorionic decidua biological specimens, and then follow up on the pregnancy outcomes. The concentration of disrupting substances was detected and then found the associations between environmental endocrine disrupting substances and female reproductive health.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 2000
Clinical diagnosis of infertile patients undergoing IVF treatment
Donor egg transplants excluded
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of eggs retrieved immediately after the eggs retrieved the number of eggs retrieved in the process of in vitro fertilization (IVF)
the miscarriage rate 7 months after embryos transfer the miscarriage rate in the process of IVF
the live birth rate 40 weeks after embryos transfer the live birth rate in the process of IVF
the number of available embryos 1 week after the eggs retrieved the number of available embryos in the process of IVF
the clinical pregnancy rate 4 weeks after the embryos transfer the clinical pregnancy rate in the process of IVF
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Peking University People's Hospital
🇨🇳Beijing, Beijing, China