Comparison of the Use of Energy Substrates and Hormonal Regulation of Blood Sugar During Exercise of Increasing Intensity Between Children With Type 1 Diabetes and Non-diabetic Control Children.

Not Applicable

• Conditions: Type 1 Diabetes
• Interventions: Procedure: controlled physical activity

• Registration Number: NCT03139864
• Lead Sponsor: University Hospital, Clermont-Ferrand

Brief Summary

The type 1 diabetes is a common chronic disease characterised by the stop of production of insulin by the pancreas. A lot of factors modify blood glucose. The objective is to study the effect of type 1 diabetes on the use of energy substrates (fats and carbohydrates) during exercise of increasing intensity by a comparison with non-diabetic controls children.

Detailed Description

The type 1 diabetes is a common chronic disease characterised by the stop of production of insulin by the pancreas. A lot of factors modify blood glucose. The objective is to study the effect of type 1 diabetes on the use of energy substrates (fats and carbohydrates) during exercise of increasing intensity by a comparison with non-diabetic controls children.

Study Timeline

• Study Start: 2017-04-04
• Study First Submitted: 2017-04-07
• Study First Submitted QC: 2017-05-02
• Study First Posted: 2017-05-04
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-01
• Last Update Posted: 2019-02-04
• Primary Completion: 2019-05
• Study Completion: 2019-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Children between 6 and 12 years
• Tanner stage <T2
• Type 1 diabetes for more than 1 year for infants with type 1 diabetes

Exclusion Criteria

• Tanner stage > ou = T2
• Obesity
• Hormonal disease
• Disease who prevent doing exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
type 1 diabetes	controlled physical activity	Comparison between infants with type 1 diabetes and infants without type 1 diabetes during exercise :
without type 1 diabetes	controlled physical activity	Comparison between infants with type 1 diabetes and infants without type 1 diabetes during exercise :

Primary Outcome Measures

Name	Time	Method
Comparison of substrate utilization between infants with type 1 diabetes and infants without type 1 diabetes during exercise	at day 1	Measurements will be carried out by indirect calorimetry and the relationship between CO2 et O2 (Metamax)

Secondary Outcome Measures

Name	Time	Method
hormonal regulation of blood glucose	at day 1	insulin, glucagon, adrenaline, cortisol and growth hormone will be metered according to their half life until 2 hours after physical activity (T12, T20, T40, T60, T120)
lipoxmax : the intensity for wich lipid oxydation is maximum will be carried out by indirect calorimetry	at day 1	during exercise
Comparison between infants during 10 days before and 4 days after exercise of blood glucose modification	10 days before and 4 days after exercise of blood glucose modification	Comparison of curves of interstitial blood glucose measured with Freestyle®

Trial Locations

Locations (1)

CHU Clermont-Ferrand; 🇫🇷 Clermont-Ferrand, France