A comparative study of 12 hour versus 24 hour Modified Pritchard regimen in the management of Eclampsia and Preeclampsia

Not Applicable

Completed

• Conditions: Circulatory System; Pregnancy and Childbirth; Preeclampsia and Eclampsia

• Registration Number: PACTR201811515303983
• Lead Sponsor: niversity of Michigan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-07
• Last Update Posted: 2023-05-29

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 730

Inclusion Criteria

1.Antepartum, intrapartum, or postpartum eclampsia with a blood pressure of 140/90 mm Hg or higher after 20 weeks of pregnancy; proteinuria with a dipstick value of +1 or higher; and seizures not attributed to other causes among women with preeclampsia.
2.Severe preeclampsia with diastolic BP=110 mmHg on two occasions or systolic BP =160 mmHg plus at least 2 or more symptoms of imminent eclampsia
3.Patients who have documentation of having received loading dose of MgSO4 at referral clinics prior to referral will be eligible for randomization if they otherwise

Exclusion Criteria

1.Eclampsia with complications (e.g. acute renal failure, HELLP syndrome [hemolysis, elevated liver enzymes, and low platelet count], or pulmonary edema) or
2.Patients with underlying renal disease
3.Contraindication to MgSO4 (e.g. drug hypersensitivity, myasthenia gravis, anuria, or oliguria),
4.Prior intake of any other anticonvulsant, and a history of epilepsy.
5.Refusal to give consent or unable to give consent (eg unconscious)

Study & Design

• Study Type: Interventional
• Study Design: Not specified