Hypothyroidism in Patients With Type 2 Diabetes With Early Diabetic Nephropathy
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- percentage of hypothyroidism in patients of type 2 diabetes with diabetic nephropathy
研究概览
简要总结
Diabetes Mellitus is the most common disorder seen. The impact of this disease on the quality of life, and on morbidity and mortality through the complications that affect the small and large vessels resulting in retinopathy, nephropathy, neuropathy, and ischemic heart disease has been emphasized by the findings of the national commission (USA) on diabetes .
So, there was curiosity to understand and learn the association of this disorder with another common endocrine gland function that is thyroid gland . The association between these two disorders has long been recognized although the prevalence of thyroid dysfunction in diabetic population varies widely between studies. With insulin and thyroid hormone being intimately involved in cellular metabolism and thus excess or deficit of these hormones result in functional derangement of the other.
详细描述
Diabetic patients have higher prevalence of thyroid disorder when compared with the normal population. Diabetic women are more frequently affected than men and hypothyroidism is more common than thyrotoxicosis .
Sub-clinical hypothyroidism is an independent risk factor for development of diabetic nephropathy. Severe hypothyroidism (biochemically) may be completely asymptomatic. Though our patient had throid stimulating hormone level more than 100 mIU/L, he did not have any symptoms of hypothyroidism.so diagnosis of hypothyroidism depends on laboratory parameters rather than clinical findings Recognition and treatment of hypothyroidism in diabetic patients will benefit glycemic control and improve general well-being ). Diabetic nephropathy, a major micro-vascular complication of type 2 diabetes mellitus, is an important cause of chronic kidney disease. It results from interactions between hemodynamic and metabolic factors .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with Type 2 diabetes mellitus and with diabetic nephropathy.
- •All diabetics irrespective of glucose control.
- •All diabetics irrespective of treatment (oral hypoglycemic drugs/insulin)
排除标准
- •Type 1 diabetes mellitus 2) Patients with:
- •Gestational diabetes mellitus.
- •Pancreatitis.
- •Steroid induced Diabetes.
- •hepatobiliary disease
- •on systemic drug therapy such glucocorticoids and oral contraceptives.
结局指标
主要结局
percentage of hypothyroidism in patients of type 2 diabetes with diabetic nephropathy
时间窗: one year
次要结局
未报告次要终点
研究者
maria hamdy
Assiut University
Assiut University