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Clinical Trials/NCT05093413
NCT05093413
Completed
Not Applicable

Olfactory Decision-making and Deprived Sleep

Northwestern University1 site in 1 country46 target enrollmentJanuary 14, 2021
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ConditionsSleep Deprivation

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Sleep Deprivation
Sponsor
Northwestern University
Enrollment
46
Locations
1
Primary Endpoint
Behavior an olfactory perceptual decision-making task
Status
Completed
Last Updated
3 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

This research study will use magnetic resonance imaging (MRI) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.

Registry
clinicaltrials.gov
Start Date
January 14, 2021
End Date
May 19, 2022
Last Updated
3 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Christina Zelano

Principal Investigator

Northwestern University

Eligibility Criteria

Inclusion Criteria

  • •At least 18 years old
  • •Fluent English speakers

Exclusion Criteria

  • •History of neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.)
  • •History of psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, alcoholism, etc.)
  • •Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.)
  • •Cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.)
  • •Use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.)
  • •Smell or taste dysfunction
  • •History of severe allergies requiring hospitalization for treatment
  • •History of severe asthma requiring hospitalization for treatment
  • •Habitual smoking
  • •History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.)

Outcomes

Primary Outcomes

Behavior an olfactory perceptual decision-making task

Time Frame: Up to 24 hours after the intervention

Food-like perceptual responses to binary food-nonfood odor mixtures

Secondary Outcomes

  • Resting-state functional magnetic resonance imaging(Up to 24 hours after the intervention)

Study Sites (1)

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