NCT05093413CompletedNot Applicable
Olfactory Decision-making and Deprived Sleep
Northwestern University2 sites in 1 country46 target enrollmentStarted: January 14, 2021Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Northwestern University
- Enrollment
- 46
- Locations
- 2
- Primary Endpoint
- Behavior an olfactory perceptual decision-making task
Study Overview
Brief Summary
This research study will use magnetic resonance imaging (MRI) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •At least 18 years old
- •Fluent English speakers
Exclusion Criteria
- •History of neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.)
- •History of psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, alcoholism, etc.)
- •Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.)
- •Cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.)
- •Use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.)
- •Smell or taste dysfunction
- •History of severe allergies requiring hospitalization for treatment
- •History of severe asthma requiring hospitalization for treatment
- •Habitual smoking
- •History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.)
- •Dieting or fasting
- •History of sleep disorders (e.g., obstructive sleep apnea, narcolepsy, insomnia, etc.) Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.)
- •Electronic implants (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.)
- •History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers
- •Left-handedness
- •Claustrophobia
Outcomes
Primary Outcomes
Behavior an olfactory perceptual decision-making task
Time Frame: Up to 24 hours after the intervention
Food-like perceptual responses to binary food-nonfood odor mixtures
Secondary Outcomes
- Resting-state functional magnetic resonance imaging(Up to 24 hours after the intervention)
Investigators
Christina Zelano
Principal Investigator
Northwestern University
Study Sites (2)
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