BRRIDE 2 - Breast Risk Reduction Intermittent Diet Evaluatio

Not Applicable

Completed

• Conditions: Topic: Cancer; Subtopic: Breast Cancer; Disease: Breast; Cancer

• Registration Number: ISRCTN10803394
• Lead Sponsor: niversity Hospital of South Manchester NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-01-12
• Study Completion: 2015-06-30
• Last Update Posted: 31 August 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 26

Inclusion Criteria

1. Family history of breast cancer (lifetime risk >1 in 6)
2. Premenopausal aged >30-45 years
3. Body mass index 30-45 kg/m2.
4. Nonsmoker
5. Sedentary (< 40 minutes moderate exercise per week)

Exclusion Criteria

1. Contradindication to MR imaging (e.g pacemaker, weight greater than 125kg)
2. Already successfully losing weight.
3. Pregnant or planning pregnancy over next 5 months
4. Currently Breast feeding
5. Eating disorder, depression or alcoholism
6. Alcohol intake greater than 10g of ethanol (10 units) per week
7. Comorbidity that affects liver fat stores i.e. NonAlcoholic Fatty Liver Disease, diabetes, viral hepatitis, fibrosis, Human Immunodeficiency Virus, coeliac disease
8. Drug use current or within the past 6 months affecting liver fat content i.e. insulin, oral contraceptives, tamoxifen, statins, amiodarone, methotrexate, corticosteroids
9. Previous or current history of cancer
10. Following an incompatible therapeutic diet

Study & Design

• Study Type: Interventional
• Study Design: Not specified