Proteogenomic approach to reveal age-specific molecular mechanisms of laryngeal squamous cell carcinomas

Recruiting

• Conditions: cancer of the voice box; Head and neck cancer; Laryngeal squamous cell carcinoma; 10038666; 10029107

• Registration Number: NL-OMON46665
• Lead Sponsor: Keel-, neus-, oorheelkunde en hoofd-halschirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 144

Inclusion Criteria

- Newly diagnosed squamous cell carcinoma of the larynx
- Age >18 years;
- Written informed consent;
- WHO performance status: 0-2.

Exclusion Criteria

- Previous treatment of head and neck cancer;
- Previous radiation therapy in the head and neck area;
- Diagnostic procedure in an emergency situation (e.g. severe dyspnoea);
- Histological diagnosis other than squamous cell carcinoma.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Identify molecular differences in carcinogenesis of LSCC between younger (<70<br /><br>years) and elderly (>70 years) patients through an integrated proteogenomic<br /><br>analysis of laryngeal tissue biopsies</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Investigate whether these molecular differences are associated with patients*<br /><br>oncological outcome in terms of laryngeal preservation rate, disease-free<br /><br>survival, disease-specific survival and overall patient survival. </p><br>