Endovascular Treatment of Wide Neck Saccular Cerebral Aneurysms

Not Applicable

Recruiting

• Conditions: Wide Neck Saccular Cerebral Aneurysms
• Interventions: Procedure: Endovascular procedure of treatment of wide neck saccular cerebral aneurysm

• Registration Number: NCT05796986
• Lead Sponsor: Sohag University

Brief Summary

Intracranial aneurysm (IA) is a cerebrovascular disorder in which the weakness of a cerebral artery wall causes a localized dilation of the blood vessel. Intracranial aneurysm can develop and rupture, and about 85% of spontaneous subarachnoid hemorrhage (SAH) cases are caused by the rupture of Intracerebral aneurysm.

Two treatments are available globally: microsurgical clipping and endovascular treatment.

Endovascular treatment of Intracerebral aneurysms using detachable platinum coils ( was introduced in 1990 by Guido Guglielmi, an Italian neurosurgeon ) of different shapes and sizes are deposited into the aneurysm through a microcatheter, which reduces the blood flow and induces thrombus formation .

Wide neck aneurysm defined by neck diameter greater than 4 mm or dome-to-neck ratio less than 2 Despite advances in endovascular techniques , the treatment of wide-necked aneurysms remains problematic . Endovascular treatment of intracranial aneurysms is associated with lower morbidity and mortality rates and faster recovery compared with traditional microsurgical clipping.

In wide-necked Intracerebral aneurysms, complete coil embolization is often technically difficult owing to the risks of distal coil migration or coil impingement on the parent vessel .

Complete coil embolization using a single microcatheter without a supporting device in cases of wide-necked Intracerebral aneurysm is technically difficult. Total occlusion rates have increased recently as a result of the advancement of supporting devices These may include balloon remodeling, use of three-dimensional (3D) coils (Russian Doll Technique), combined use of stents and coils (Stent assisted coiling), flow diverters, use of intrasaccular flow disruption (like WEB), Double catheter Technique or combined extra- and intrasaccular devices.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2022-01-01
• Study First Submitted: 2023-03-14
• Study First Submitted QC: 2023-04-03
• Study First Posted: 2023-04-04
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-15
• Last Update Posted: 2024-04-16
• Primary Completion: 2024-10-01
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• All patients of spontaneous subarachnoid haemorrhage due to ruptured wide neck saccular cerebral aneurysms
• unruptured Denovo wide neck saccular cerebral aneurysms

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Exclusion Criteria

• other forms of cerebral aneurysms rather than saccular type : fusiform and dissecting aneurysms
• complex aneurysms : giant and thrombosed aneyrsms
• any spontaneous subarachnoid haemorrhage with world fedriation of neurosurgery societies (WFNS) Grade 4&5
• Any patient unfit for general anesethia or has serious renal impairment

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Wide neck saccular cerebral aneurysms patients	Endovascular procedure of treatment of wide neck saccular cerebral aneurysm	-

Primary Outcome Measures

Name	Time	Method
efficacy of procedure	1 year	degree of aneurysm occlusion classifeid by Raymond Roy classification

Trial Locations

Locations (1)

Sohag University Hospital; 🇪🇬 Sohag, Egypt