Effects of Spatial Cognitive Training using Virtual Reality on Hippocampal functions and Activity in Prefrontal Cortex of Older Adults with Mild Cognitive Impairment

Phase 2

Completed

• Conditions: Patients with mild cognitive impairment; Spatial cognition; Episodic memory; Prefrontal cortex; Virtual reality; Hippocampus

• Registration Number: TCTR20191020002
• Lead Sponsor: There is no sponsor

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-08-23
• Study Start: 2019-10-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

(a) subjective memory complaint
(b) objective memory impairment defined by score on the Seoul Neuropsychological Screening Battery
(c) intact general cognitive function as determined by score on the Korean version of the Mini-Mental State Examination (MMSE-K)
(d) intact activities of daily living as determined by score on the Seoul instrumental activities of daily living score

Exclusion Criteria

(a) dementia diagnosed by physicians
(b) presence of neurological or psychiatric disorders
(c) moderate or severe depressive symptom as determined by score on the Korean version of the Geriatric Depression Scale
(d) presence of auditory or visual impairments
(e) participation in any programs to improve cognitive function within one month.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Spatial cognition Before and after the 8-week intervention the Weschsler Adult Intelligence Scale-Revised Block Design test,Episodic memory Before and after the 8-week intervention The Seoul Verbal Learning Test

Secondary Outcome Measures

Name	Time	Method
Acitivy in prefrontal cortex Before and after the 8-week intervention Changes in oxygenated hemoglobin