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Clinical Trials/NCT00453752
NCT00453752UnknownNot Applicable

Non-Invasive Diagnostic and Functional Evaluation of Cardiac Involvement in Patients With Systemic Sclerosis

Medical University of Warsaw1 site in 1 country100 target enrollmentStarted: April 2006Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Sponsor
Enrollment
100
Locations
1
Study OverviewStudy DesignEligibility CriteriaInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in systemic sclerosis patients and to establish whether it reflects the severity of RV overload.

Detailed Description

Elevated serum brain natriuretic peptide (BNP) levels released from myocytes of ventricles upon stretch have been found in patients with isolated right ventricular (RV) pressure overload. However, limited data suggest that serum BNP may be elevated in patients with systemic sclerosis (SSc), especially with RV dysfunction. The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in SSc patients and to establish whether it reflects the severity of RV overload.

Study Design

Study Type
Observational
Observational Model
Defined Population
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Clinical diagnosis of systemic sclerosis

Exclusion Criteria

  • •Cardiovascular disorders other than pulmonary hypertension
  • •Significant pulmonary function abnormalities
  • •Impaired renal function

Investigators

Sponsor
Medical University of Warsaw
Sponsor Class
Other

Study Sites (1)

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