Non-Invasive Diagnostic and Functional Evaluation of Cardiac Involvement in Patients With Systemic Sclerosis

• Conditions: Systemic Sclerosis

• Registration Number: NCT00453752
• Lead Sponsor: Medical University of Warsaw

Brief Summary

The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in systemic sclerosis patients and to establish whether it reflects the severity of RV overload.

Detailed Description

Elevated serum brain natriuretic peptide (BNP) levels released from myocytes of ventricles upon stretch have been found in patients with isolated right ventricular (RV) pressure overload. However, limited data suggest that serum BNP may be elevated in patients with systemic sclerosis (SSc), especially with RV dysfunction. The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in SSc patients and to establish whether it reflects the severity of RV overload.

Study Timeline

• Status Verified: 2006-03
• Study Start: 2006-04
• Study First Submitted: 2007-03-28
• Study First Submitted QC: 2007-03-28
• Last Update Submitted: 2007-03-28
• Study First Posted: 2007-03-29
• Last Update Posted: 2007-03-29
• Study Completion: 2010-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Clinical diagnosis of systemic sclerosis

Exclusion Criteria

• Cardiovascular disorders other than pulmonary hypertension
• Significant pulmonary function abnormalities
• Impaired renal function

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Michał Ciurzyński; 🇵🇱 Warsaw, Lindleya 4, Poland