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临床试验/NCT02855398
NCT02855398已完成不适用

Understanding Decision-Making and the Relationship to Food Intake in Children 7 to 11 Years Old

Penn State University1 个研究点 分布在 1 个国家目标入组 142 人开始时间: 2015年4月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
142
试验地点
1
主要终点
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).

研究概览

简要总结

The purpose of this 18-month project is to investigate how decision-making influences food choice and consumption in children ages 7 to 11 years old. Although several studies suggest that the ability to make good decisions relates to eating behaviors, no studies have looked at how food reward influences the decision-making process to impact actual food intake. This proposal will answer these questions and bridge this gap in knowledge, which could lead to the development of more effective interventions for childhood obesity. To accomplish this, the investigators have assembled a diverse team with expertise in food intake, nutrition, and decision sciences. First, the investigators will establish if there are differences in decision-making between children varying in weight status. Second, the investigators will determine if performance on behavioral decision-making tasks relates to food consumption in the laboratory. Third, the investigators will examine response functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) response to various rewards (i.e. food and money) and determine if this is influenced by child weight status. Fourth, the investigators will examine differences in fMRI BOLD at rest in decision-making regions are correlated with food intake and weight status. Eighty-two children will participate in our study. The long-term goal of this project is to investigate if there are differences in brain regions corresponding to these behaviors in overweight children and if these differences relate to eating behaviors in this population. Children will undergo fMRI while playing a reward task as well as consume meals in our laboratory. Decision-making will also be assessed by having children complete various behavioral measurements of reward and inhibitory control.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Cross Sectional

入排标准

年龄范围
7 Years 至 11 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Right-handed
  • English as native language
  • Reading at/above grade level
  • Not Claustrophobic
  • Generally Healthy

排除标准

  • Left-handedness
  • Metal in or on body that cannot be removed
  • Claustrophobia
  • Medication usage that may alter brain activity or blood flow
  • Medical disorder that may impact comfort of safety in MRI scanner
  • Food Allergies
  • Dietary Restrictions
  • Learning Disabilities
  • Psychiatric Disorders

结局指标

主要结局

Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).

时间窗: Collected at fMRI scan at week 4

Regions of interest BOLD analysis of an fMRI card-guessing task for various reward types

Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at rest (resting-state fMRI)

时间窗: Collected at fMRI scan at week 4

Regions of interest BOLD analysis of resting-state fMRI to examine differences in brain regions of interest at rest

Behavioral inhibitory control task

时间窗: Collected at either week 1-3 (randomized)

Measured by performance on a go/nogo task

Behavioral reward inhibitory control task

时间窗: Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)

Measured by performance on a go/nogo task with a reward incentive

Behavioral risk-taking and reward task

时间窗: Collected at either week 1-3 (randomized)

Measured by performance on the hungry donkey task

Behavioral dietary self-control assessment

时间窗: Collected at either week 1-3 (randomized)

Measured by performance on a dietary self-control task

次要结局

  • Energy intake at baseline(Collected at either week 1-3 (randomized))
  • Energy intake at a buffet meal(Collected at either week 1-3 (randomized))
  • Energy intake after a meal preload(Collected at either week 1-3 (randomized) following the baseline meal)
  • Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).(Collected at week 4)
  • Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at baseline(Collected at week 4)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Kathleen Loralee Keller

Assistant Professor, Department of Nutritional Sciences and Food Science

Penn State University

研究点 (1)

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