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Clinical Trials/NCT02855398
NCT02855398
Completed
Not Applicable

Understanding Decision-Making and the Relationship to Food Intake in Children 7 to 11 Years Old

Penn State University1 site in 1 country142 target enrollmentApril 2015

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Pediatric Obesity
Sponsor
Penn State University
Enrollment
142
Locations
1
Primary Endpoint
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).
Status
Completed
Last Updated
5 years ago

Overview

Brief Summary

The purpose of this 18-month project is to investigate how decision-making influences food choice and consumption in children ages 7 to 11 years old. Although several studies suggest that the ability to make good decisions relates to eating behaviors, no studies have looked at how food reward influences the decision-making process to impact actual food intake. This proposal will answer these questions and bridge this gap in knowledge, which could lead to the development of more effective interventions for childhood obesity. To accomplish this, the investigators have assembled a diverse team with expertise in food intake, nutrition, and decision sciences. First, the investigators will establish if there are differences in decision-making between children varying in weight status. Second, the investigators will determine if performance on behavioral decision-making tasks relates to food consumption in the laboratory. Third, the investigators will examine response functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) response to various rewards (i.e. food and money) and determine if this is influenced by child weight status. Fourth, the investigators will examine differences in fMRI BOLD at rest in decision-making regions are correlated with food intake and weight status. Eighty-two children will participate in our study. The long-term goal of this project is to investigate if there are differences in brain regions corresponding to these behaviors in overweight children and if these differences relate to eating behaviors in this population. Children will undergo fMRI while playing a reward task as well as consume meals in our laboratory. Decision-making will also be assessed by having children complete various behavioral measurements of reward and inhibitory control.

Registry
clinicaltrials.gov
Start Date
April 2015
End Date
December 2017
Last Updated
5 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Kathleen Loralee Keller

Assistant Professor, Department of Nutritional Sciences and Food Science

Penn State University

Eligibility Criteria

Inclusion Criteria

  • Right-handed
  • English as native language
  • Reading at/above grade level
  • Not Claustrophobic
  • Generally Healthy

Exclusion Criteria

  • Left-handedness
  • Metal in or on body that cannot be removed
  • Claustrophobia
  • Medication usage that may alter brain activity or blood flow
  • Medical disorder that may impact comfort of safety in MRI scanner
  • Food Allergies
  • Dietary Restrictions
  • Learning Disabilities
  • Psychiatric Disorders

Outcomes

Primary Outcomes

Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).

Time Frame: Collected at fMRI scan at week 4

Regions of interest BOLD analysis of an fMRI card-guessing task for various reward types

Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at rest (resting-state fMRI)

Time Frame: Collected at fMRI scan at week 4

Regions of interest BOLD analysis of resting-state fMRI to examine differences in brain regions of interest at rest

Behavioral inhibitory control task

Time Frame: Collected at either week 1-3 (randomized)

Measured by performance on a go/nogo task

Behavioral reward inhibitory control task

Time Frame: Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)

Measured by performance on a go/nogo task with a reward incentive

Behavioral risk-taking and reward task

Time Frame: Collected at either week 1-3 (randomized)

Measured by performance on the hungry donkey task

Behavioral dietary self-control assessment

Time Frame: Collected at either week 1-3 (randomized)

Measured by performance on a dietary self-control task

Secondary Outcomes

  • Energy intake at baseline(Collected at either week 1-3 (randomized))
  • Energy intake at a buffet meal(Collected at either week 1-3 (randomized))
  • Energy intake after a meal preload(Collected at either week 1-3 (randomized) following the baseline meal)
  • Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).(Collected at week 4)
  • Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at baseline(Collected at week 4)

Study Sites (1)

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