A Study Using 18F-FAPI PET to Evaluate Treatment Response in Pancreatic Adenocarcinoma

Completed

• Conditions: Pancreas Adenocarcinoma; Pathologic Response; Systemic Treatment; 18F-FAPI

• Registration Number: NCT06277206
• Lead Sponsor: Zhejiang University

Brief Summary

To explore the potential utility of 18F-FAPI-04 PET/CT for pathologic response evaluation to systemic treatment in PDAC

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-04
• Primary Completion: 2023-11-19
• Status Verified: 2024-02
• Study Completion: 2024-02-10
• Study First Submitted: 2024-02-17
• Study First Submitted QC: 2024-02-23
• Last Update Submitted: 2024-02-23
• Study First Posted: 2024-02-26
• Last Update Posted: 2024-02-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

• suspected to have pancreatic cancer by radiological imaging
• planned systemic treatment
• possibility of conversion surgery
• willingness to participate the study

Exclusion Criteria

• without pathologically confirmed pancreatic cancer
• poor performance status or organ functions that cannot meet the systemic treatment requirements
• metastatic disease
• pregnant patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change of Mean standardized uptake value	Baseline and preoperation	Change of SUVmean before and after treatment
Change of Maximum standardized uptake value	Baseline and preoperation	Change of SUVmax before and after treatment

Secondary Outcome Measures

Name	Time	Method
Mean standardized uptake value	Baseline	Baseline SUVmean at diagnosis
Change of Total Lesion FAP expression	Baseline and preoperation	Change of TLF before and after treatment
Maximum standardized uptake value	Baseline	Baseline SUVmax at diagnosis
Change of Metabolic Tumor Volume	Baseline and preoperation	Change of MTV before and after treatment
Total Lesion FAP expression	Baseline	Baseline TLF at diagnosis
Metabolic Tumor Volume	Baseline	Baseline MTV at diagnosis

Trial Locations

Locations (1)

First Affiliated Hospital, Medical College of Zhejiang University; 🇨🇳 Hangzhou, Zhejiang, China