The Evaluation of the Protective Effect of N-Acetylcysteine Against Drug Induced Ototoxicity in Peritoneal Dialysis Patients

TC Erciyes University1 site in 1 country60 target enrollmentFebruary 2008

ConditionsDrug-induced Ototoxicity in Peritoneal Dialysis Patients

InterventionsN-acetylcysteine

DrugsN-acetylcysteine

Overview

Phase: Phase 2
Intervention: N-acetylcysteine
Conditions: Drug-induced Ototoxicity in Peritoneal Dialysis Patients
Sponsor: TC Erciyes University
Enrollment: 60
Locations: 1
Status: Completed
Last Updated: 15 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to determine whether N-acetylcysteine is effective in the prevention of hearing loss in both ears due to aminoglycoside and/or vancomycine induced ototoxicity in peritoneal dialysis patients.

Registry

clinicaltrials.gov

Start Date

February 2008

End Date

May 2010

Last Updated

15 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

TC Erciyes University

Eligibility Criteria

Inclusion Criteria

•End-stage renal disease
•Undergoing continuous ambulatory peritoneal dialysis as a renal replacement therapy
•Clinical diagnosis of a peritonitis episode in a continuous ambulatory peritoneal dialysis patient
•Developing the first continuous ambulatory peritoneal dialysis related peritonitis episode

Exclusion Criteria

•Being treated with aminoglycoside antibiotics and vancomycine within the previous 3 months
•Detection of mechanical occlusion of external ear
•Having signs of disturbed integrity of tympanic membrane on otoscopy or tympanometry
•History of a continuous ambulatory peritoneal dialysis related peritonitis