Matrix Metalloproteinase (MMP) in Heart Failure

Completed

• Conditions: Chronic Stable Heart Failure

• Registration Number: NCT00663494
• Lead Sponsor: Tottori University Hospital

Brief Summary

The purpose of this study is to evaluate the production of MMP in failing hearts.

Detailed Description

Myocardial fibrosis is observed in failing hearts and parallel to the progression of chronic heart failure (CHF) and myocardial remodeling. Matrix metalloproteinases (MMPs) are considered markers of fibrosis. Recently, circulating MMPs can be measured and are elevated in patients with CHF. However, MMPs it is still unclear whether MMPs are produced in failing hearts. Thus, the purpose of this study is to evaluate the production of MMP in failing hearts.

Study Timeline

• Study Start: 2003-02
• Study Completion: 2006-07
• Status Verified: 2008-04
• Study First Submitted: 2008-04-18
• Study First Submitted QC: 2008-04-18
• Study First Posted: 2008-04-22
• Last Update Submitted: 2011-07-20
• Last Update Posted: 2011-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• chronic stable heart failure

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MMPs level of coronary sinus