Comparing end tidal sevoflurane in cirrhotic and non cirrhotic patients undergoing major hepatic resection using bispectral index

Not Applicable

Active, not recruiting

• Conditions: SevofluraneBispectralindex(BIS)Minimal alveolar concentration(MAC)CirrhosisHepatic resection; Sevoflurane; Bispectralindex(BIS); Minimal alveolar concentration(MAC); Cirrhosis; Hepatic resection

• Registration Number: TCTR20170929002
• Lead Sponsor: none

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-29
• Study Completion: 2018-08-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

- patient who was scheduled for major hepatic resection(definition is anatomic hepatic resection more than 2 segments such as right hepatectomy, left hepatectomy , extended right hepatectomy , left lobectomy or extended left hepatectomy) with specialty hepatobiliary surgeon under combined general-epidural anesthesia at King Chulalongkorn Memorial Hostipal
- age 20-65 years
- American Society of Anesthesiology Physical Status (ASA) I-III
ASA I : A normal healthy patient (Examples include Healthy, non-smoking, no or minimal alcohol use)
ASA II : A patient with mild systemic diseaseMild diseases only without substantive functional limitations (Examples include current smoker, social alcohol drinker, pregnancy, obesity (30 < BMI < 40), well-controlled DM/HTN, mild lung disease)
ASA III : A patient with severe systemic disease (Substantive functional limitations; One or more moderate to severe diseases. Examples include (but not limited to): poorly controlled DM or HTN, COPD, morbid obesity (BMI ≥40), active hepatitis, alcohol dependence or abuse, implanted pacemaker, moderate reduction of ejection fraction, ESRD undergoing regularly scheduled dialysis, premature infant PCA < 60 weeks, history (>3 months) of MI, CVA, TIA, or CAD/stents.)

Exclusion Criteria

- refuse to participate this study
- allergy to any drug in this study
- serious diseases other than liver diseases, such as cardiovascular, respiratory or
endocrine system conditions
- contraindication for epidural catheter
- taking chronic sedatives drug and opioid
- alcoholics or drug abuse
- psychaitic problems
- a body mass index (BMI) ≥30 kg/m 2
- history of malignant hyperthermia

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
End tidal Sevoflurane Peri-operative peroid Percentage of end tidal Sevoflurane during peri-operative peroid

Secondary Outcome Measures

Name	Time	Method
Volume of Sevoflurane consumption Peri-operative peroid milliliter of Sevoflurane consumption ,minimal alveolar concentration(MAC) Peri-operative peroid mean of minimal alveolar concentration(MAC)