Assessment of the protective effect of sunscreen by measuring UV-biomarkers

Completed

Conditions: skin cancer
non-melanoma skin cancer
10014982

Registration Number: NL-OMON48352

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

Male and female individuals between 18 and 65 years.
Fitzpatrick skin types II or III.
Free of any dermatological or systemic disorder which would interfere with the
results, at the discretion of the investigator.
Individual who has read, understood and signed an informed consent document
relating to the specific study to which he/she is subscribing.
Individuals with no known abnormal response to sunlight (e.g. polymorphic
eruption) or (ingredients of) sunscreens.
Willingness to actively participate in the study and come to the scheduled
visits
Willingness to discontinue the use of detergents (e.g. soaps) and cosmetics
products (e.g. creams, moisturizers) in the treatment area throughout the
course of the study
Willingness to avoid any exposure of the test area to artificial or natural
ultraviolet light throughout the course of the study

Exclusion Criteria

Taking medication which in the opinion of the investigator would mask or
interfere with the results.
With chronic skin allergies.
With suntan of sunburn
Breastfeeding
Pregnancy or intention to become pregnant over the duration of the study
Participation in, or being in the waiting period for another study
Individual with moles, tattoos, scars, irritated skin, hairs, etc. at the test
area that could influence the investigation.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The levels of urocanic acid isomers, immunological factors (chemokines,<br /><br>cytokines, MMP (metalloproteinases)), and angiogenesis factors in the the<br /><br>stratum corneum. </p><br>

Secondary Outcome Measures