Pain control effectiveness of curcumin compare with ibuprofen after lower third molar removal surgery and A double blind randomized clinical trial

Phase 4

• Conditions: Patients who have indication surgical removal of lower third molar Impacted tooth (moderate point of pell and gregory classification); Curcumin, Ibuprofen, Analgesic, impacted tooth, Post operative pain

• Registration Number: TCTR20220705002
• Lead Sponsor: Ministry of Higher Education, Science, Research and Innovation, Prince of Sonkla University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-05
• Study Completion: 2023-02-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Unknown
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

1. Patients aged between 18 to 29 years
2. Weight 40-90 kgs
3. Clear indication for removal of lower third molars
3. Health patients with no uncontrolled systemic disease that is unsuitable to lower the third molar impacted
4. The moderate difficulty of lower third molar (Pederson difficulty index 5-6 score)
5. Operation time must be less or equal to 1 hour
6. An absence of periodontal disease, infection, swelling before surgery
7. Same person to surgery second time greater than or equal to 3 weeks

Exclusion Criteria

1. Taking analgesic medications, such as aspirin, paracetamol, NSAIDs, opioids, or any other agents between 24 hours and 2 weeks before surgery
2. Patients with a history of severe asthma, gastrointestinal disorders such as Dyspepsia or Peptic ulcer(PU)) Bile duct obstruction, hematologic, renal, or hepatic disease; immunosuppressive disorder; neurological disorder affecting pain perception
3. Taking medication (use anticoagulant or antiplatelet, cancer drugs)
4. Pregnancy and Lactation
Allergy to Local anesthetic, NSAID(Ibuprofen), curcumin, amoxicillin, tramadol, and paracetamol
5. Smoking

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain score after surgical removal of lower third molar impacted tooth 1, 2, 6,12, 24,48,72 hour and 7 days visual analog scale (VAS) 1-10

Secondary Outcome Measures

Name	Time	Method
/A N/A N/A