Is evening exercise superior to morning exercise for improving glycemic control in individuals with type 2 diabetes?

Not Applicable

Recruiting

Conditions: E11
Type 2 diabetes mellitus

Registration Number: DRKS00027872

Lead Sponsor: DLR - Institut für Luft- Und RaumfahrtAbteilung für für Muskel- und Knochenstoffwechsel

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 15

Inclusion Criteria

Type 2 diabetes diagnosis according to ADA criteria, not physically active (<1 h of structured
exercise per week), BMI between 19 and 35 kg/m2
), male and female sex, capacity to consent,
aged 30 to 69 years of age

Exclusion Criteria

Weight fluctuations of more than 10% within the last 6 months, therapy with glitazones, betablockers or insulin, peripheral artery occlusive disease IV, venous thromboembolic events, existing or past foot ulcers, electrocardiogram abnormalities (alterations of the ST segment, higher-grade arrhythmia), unstable angina pectoris, uncontrolled hypertension, heart-, renal-and liver-failure (NYHA =II, serum creatinine =1.6 mg/dl, Aspartate-Aminotransferase/ Alanine-Aminotransferase/Gamma-Glutamyltransferase), Claustrophobia

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Average 24 h glucose (mg/dl) from continuous glucose monitoring

Secondary Outcome Measures

Name	Time	Method
Changes of glucose metabolism: glucose, insulin and glucagon concentrations<br>Changes of lipid metabolism: chylomicrons, VLDL, HDL, TG concentrations<br>Peripheral and hepatic insulin sensitivity<br>Characterization of postprandial glucose metabolism using stable isotope 13C-glucose tracer<br>Adipose tissue: adipocyte size and inflammatory status<br>Mitochondrial function in skeletal muscle and adipose tissue<br>Body composition<br>Aerobic performance and muscle strength <br>Energy turnover and substrate utilization<br>Expression of clock genes and proteomics of skeletal muscle<br>Metabolite analysis of plasma, muscle and adipose tissue<br>