Evaluating the effect of Dorzolamide vs Netarsudil in Preperimetric and Early Glaucoma- A Randomised Controlled Trial - NI

Dr Rajendra Prasad Centre for Ophthalmic Sciences0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年4月1日

试验速览

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•Preperimetric Glaucoma-
•Age over 40 years
•Open angle in gonioscopy
•Baseline IOP = 25mmHg
•Best-corrected visual acuity 20/40 or better (refractive error ± 5.0D spherical; ± 3.0D cylinder)
•Abnormal circumpapillary RNFL thickness (cpRNFLT) in at least one quadrant on OCT scan
•A visual field within the normal limits of a glaucoma hemifield test, with pattern standard deviation (PSD) greater than 5%, confirmed in at least two examinations
•Early Glaucoma-
•BCVA 20/40 or more (refractive error ± 5.0D spherical; ± 3.0D cylinder)
•Open angles on gonioscopy
•Baseline IOP = 25mmHg
•Features suggestive of glaucomatous optic neuropathy such as cup-disc ratio >0.6 and any diffuse or focal neuroretinal rim thinning 2 consecutive abnormal visual field tests defined as PSD outside 95% normal confidence limits and a GHT classified as ‘‘outside normal limits’’ as defined by the Hodapp-Parrish-Anderson (HPA) criteria for early glaucoma

•Patients with moderate or advanced glaucoma (MD worse than -6 dB)
•Patients with media opacity precluding good-quality OCT scans such as corneal opacity, cataracts, etc.
•History of intraocular diseases, complicated intraocular surgery, secondary glaucoma
•Age < 40 years
•Coexisting retinal disease (for example, diabetic retinopathy)
•Other diseases affecting visual field
•Patients on vasodilatory drugs such as Nitroglycerin

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