Effect of Preoperative Alprazolam on the Success of Inferior Alveolar Nerve Block for Teeth With Irreversible Pulpitis
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- the success rate of the IAN block
研究概览
简要总结
The purpose of this prospective, randomized, double-blind, placebo-controlled study is to evaluate the effect of preoperative administration of alprazolam on the success of the IAN block for teeth with irreversible pulpitis.
详细描述
Sixty patients diagnosed with irreversible pulpitis of a mandibular molar randomly receive, in a double-blind manner, identical capsules of either 0.50 mg alprazolam or placebo 45 minutes before the administration of a conventional IAN block. Access is begun 15 minutes after completion of the IAN block, and all patients profound lip numbness. Success is defined as no or mild pain based on visual analog scale recordings during access preparation and initial instrumentation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with active pain in a mandibular molar
- •prolonged response to cold testing with Endo-Frost cold spray
- •Absence of any periapical radiolucency on radiographs
- •a vital pulp while access cavity preparation
- •ability to understand the use of pain scales.
排除标准
- •patients were having allergy and sensitivity to benzodiazepines
- •pregnant and breast feeding patients
- •patients who had taken sedation within 24 hours before the treatment
- •having pain in more than one mandibular tooth
- •unable to give informed consent
研究组 & 干预措施
alprazolam
Alprazolam is a short-acting anxiolytic of the benzodiazepine class of psychoactive drugs
干预措施: Alprazolam (Drug)
placebo
placebo capsules were filled with starch
干预措施: placebo (Drug)
结局指标
主要结局
the success rate of the IAN block
时间窗: one hour after administration of alprazolam
次要结局
- initial pain(one hour after administration of alprazolam)
研究者
Masoud Saatchi
Associate Professor of Endodontics
Isfahan University of Medical Sciences