Comparison of Palonosetron Versus Combination of Palonosetron and Dexamethasone for Preventing Postoperative Vomiting in Patients Receiving Fentanyl by Patient-controlled Analgesia After Minor Orthopedic Surgery
Not Applicable
Completed
- Conditions
- Orthopedic Surgery
- Interventions
- Registration Number
- NCT02744508
- Lead Sponsor
- Yonsei University
- Brief Summary
Postoperative nausea and vomiting (PONV) is related with extended hospital day and risk factor of aspiration pneumonia. Postoperative patient controlled intravenous analgesia is related with postoperative nausea and vomiting. Selective 5-HT3 antagonist, Palonosetron, is the most recent medication for prevention of PONV. Purpose of our study is comparison of PONV preventive effect of palonosetron and combination of palonosetron and dexamethasone.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 202
Inclusion Criteria
- patients who are undergoing minor orthopedic surgery.
- IV patient controlled analgesia
Exclusion Criteria
-
- minority (0~19 year)
- patients who are belongs to ASA class 3 or more, and have underlying complicated cardiovascular or psychological disease.
- Steroid medication
- Diabetes Mellitus medication
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description PD group palonosetron with dexamethasone Palonosetron and dexamethasone group P group palonosetron Palonosetron group
- Primary Outcome Measures
Name Time Method incidence of clinically significant PONV with PONV impact scale 72 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine
🇰🇷Seoul, Korea, Republic of