The Use of Human Acellular Dermal Matrix in the Prevention of Infraauricular Depressed Deformities and Frey's Syndrome Following Total Parotidectomy
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Parotid Tumor
- Sponsor
- West China Hospital
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- infraauricular depressed deformities and the presence of gustatory flushing or sweating
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The aim of the study was to explore whether human acellular dermal matrix (ADM) implantation could prevent infraauricular depressed deformities and Frey's syndrome following total parotidectomy.
Detailed Description
Seventy patients who underwent total parotidectomy were selected for inclusion in the study. We analyzed 41 cases of total parotidectomy (control group) and 29 cases of simultaneous ADM implantation following total parotidectomy (ADM group) for infraauricular depressed deformities and the presence of gustatory flushing or sweating. The follow-up periods ranged from 6 months to 7 years. The Results showed facial contours and bilateral symmetry improved after surgery in the ADM group. In the control group, an infraauricular depressed deformity was evident in all 41 cases. Frey's syndrome was recorded in one patient (3.4%) from the ADM group and 14 patients (34.1%) from the control group. No cases of immune rejection, infection, hematoma, or salivary fistula were observed in either group.
Investigators
Eligibility Criteria
Inclusion Criteria
- •(1) a clinical and imaging diagnosis of either a malignant parotid tumor or deep parotid tumor
- •(2) no previous surgical treatment
Exclusion Criteria
- •recurrent parotid tumors or patients who had previously undergone unsuccessful surgery
Outcomes
Primary Outcomes
infraauricular depressed deformities and the presence of gustatory flushing or sweating
Time Frame: from 6 months to 7 years after surgery
to explore whether human acellular dermal matrix (ADM) implantation could prevent infraauricular depressed deformities and Frey's syndrome following total parotidectomy