The Role of Transforming Growth Factor- Beta (TGF- β) Expression in Renal Biopsy of Lupus Nephritis Patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
- Ain Shams University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- renal biopsy
Study Overview
Brief Summary
To investigate the possible role of TGF-β expression in renal biopsy and it's relation with fibrosis, activity and chronicity indices
Detailed Description
Lupus nephritis (LN) is a common consequence of systemic lupus erythematosus and renal fibrosis is considered as a terminal pathway of the persistent immune-mediated insult .Transforming growth factor beta (TGF - β) is well recognized as a key player in LN fibrosis . A various number of cellular and molecular pathways have been incriminated as key players in the development of renal fibrosis, one of the most important main players involved in renal fibrogenesis is the transforming growth factor- β (TGF-β) signaling pathway. The investigators aim in this study to investigate the possible role of TGF-β expression in renal biopsy and it's relation with fibrosis, activity and chronicity indices
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •SLE patients who fulfilled EULAR/ACR 2019 Classification Criteria for Systemic Lupus Erythematosus , having lupus nephritis.
- •Adult population with age group from 18 to 50 years old.
Exclusion Criteria
- •Patients with any other Rheumatological diseases such as other autoimmune CT diseases or vasculitides
- •Pregnancy.
- •Ongoing or previous chemotherapy treatment for cancer.
- •Any other causes of CKD or AKI ( acute kidney injury).
Arms & Interventions
lupus nephritis patients group ( only one group)
renal biopsy will be obtained from the participants who are indicated for it.
Intervention: renal biopsy (Procedure)
Outcomes
Primary Outcomes
renal biopsy
Time Frame: 12 months
to test for the presence of Transforming Growth Factor- Beta (TGF- β) in renal biopsy of patients with lupus nephritis. All renal biopsies will be evaluated according to NIH activity and chronicity indices and fibrosis quantification according to IFTA score.
Secondary Outcomes
- clinical assessment of the patient(12 months)