ayurvedic management Of Glaucoma(primary open angle glaucoma)
- Conditions
- PATIENTS HAVING PRIMARY OPEN ANGLE GLAUCOMA
- Registration Number
- CTRI/2016/02/006582
- Lead Sponsor
- IPGT AND RA GAU
- Brief Summary
Glaucoma is the second leading cause of irreversiblevision loss in the world, responsible for approximately 15% of blindness worldwide,and it is estimated that 6.7 million of the 67 million people affected byGlaucoma worldwide are bilaterally blind (Quingley1996)1.Glaucomais not a single disease process but a group of disorders characterized by a progressiveoptic neuropathy resulting in a characteristic appearance of the optic disc anda specific pattern of irreversible visual field defects that are associatedfrequently but not invariably with raised intraocular pressure.2Severalvariants of Glaucoma exist, classified according to their etiology (i.e. congenital, primary orsecondary), but the main types are Primary Open Angle Glaucoma (POAG) andPrimary Angle Closure Glaucoma (PACG).POAG is the most common type of Glaucoma.
Managementof some of the ophthalmic condition is challenging to ophthalmologist tilltoday, POAG is one among them.Thecurrent strategy of modern management of Glaucoma is mainly concentrated onlowering intra ocular pressure. A wide range of tropical & systemic anti-glaucoma medication is available in modern science such as-β-blockers, α-agonist,miotics, prostaglandin analogs etc. and the surgical procedures include-Trabeculotomyand other fistulizing anti-glaucoma surgeries. As the known medical as well assurgical procedures have their own limitations and side effects, no doubt theseprocedures bring down some of the symptoms but at the same time create one orthe other problem.
Thereforeit was felt necessary that the herbal treatment should be tried as an effectivetherapy with minimum hazards.*Ayurveda* already have a conceptof *chakshushya* drugs which may haveneuroprotective and immuno-modulatory property which may check the GlaucomatousOptic Neuropathy (GON). In Patients of raised intra ocular tension Diuresis isone of the mechanism to reduce it. The combination like *Punarnavashtaka Kwath* &*Gokshuradi Guggulu* contains drugshaving many properties such as- *Mootravirechaka* (Diuretic), *Shothahara*(Anti-inflammatory)*,Rasayana*(Immuno-modulatory)*,**Vatanadibalya*** **(Neuroprotector)*****,*** *Chakshushya* (eye tonic) etc. In ophthalmicO.P.D. these combination have been used with encouraging results hence it wasdecided to select these two drugs internally for the present study.*Shigru pallava arka*as in *Tarpana* & *Aschyotana* (eye drops) are being used byophthalmic practitioners on Glaucoma patients and they report good results butscientific data is not reported. By virtue of its *srotoshodhaka* property it might be useful in relieving the symptomsof POAG. Safety profile of *Shigru pallavaarka* will be done first beforestartingthe *Tarpana* treatment onpatients*.* Hence it is decidedto evaluate the efficacy of *PunarnavashtakaKwath* & *Gokshuradi Guggulu*orally and *Shigru pallava arka*locally. Before starting the treatment *Kosthashodhana* will be done for 3 days by *erandbhristhaharitaki*and *Nasya* with *Anu taila* for 7 days will be done.
**GROUPING**
The selected patients will be randomly divided intotwo groups: Group A (Trial group) and Group B (Control group).There will be 15patients in each group.
**CRITERIA FOR ASSESSMENT**
**Subjective Parameters:**
- Blurred vision
- Delayed dark adaptation
**Objective Parameters:**
· Visual Acuity using snellens chart
· Schiotz or Applanation Tonometry
· Direct and indirect ophthalmoscopicexamination
· Fundus Photography
· Automated perimetry (Base line, after 2month)
· OCT (if possible) to evaluate optic disc,optic cup.
**Statistical test:** ‘t’ test will be applied forcalculating significance of the treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- All
- Target Recruitment
- 30
•Patients of POAG having IOP < 21mmHg (Normal Tensive Glaucoma) and IOP > 21 mmHg. •Visual acuity > 6/60 and clear media.
- •All types of PACG will be excluded.
- •Secondary and developmental Glaucoma including exfoliative Glaucoma, pigmentary Glaucoma, trauma induced, inflammatory Glaucoma.
- •POAG with advanced stage of optic atrophy.
- •Visual acuity < 6/60.
- •All types of cataract will be excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To propound the concept of chakshushya, rasayana, & diuretic therapy in the management of POAG. 52 days 2.To evaluate the Neuroprotective effect of Ayurvedic line of management in POAG. 52 days
- Secondary Outcome Measures
Name Time Method To assess the role of Ayurvedic line of management in lowering IOP. 52
Trial Locations
- Locations (1)
DEPT. OF SHALAKYA TANTRA
🇮🇳Jamnagar, GUJARAT, India
DEPT. OF SHALAKYA TANTRA🇮🇳Jamnagar, GUJARAT, IndiaDR SHWETA AGRAWALPrincipal investigator8690255129dr.shwetaagrawal2@gmail.com