Suspension Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 主要终点
- Blood pressure
研究概览
简要总结
Suspension syndrome refers to a potentially life-threatening condition that can occur in unconscious persons after prolonged suspension in a harness. To date, our understanding of the pathophysiology and appropriate treatment is based primarily on case reports and expert opinion. The main pathophysiological hypothesis implicates blood pooling in the lower extremity and lack of return via muscle pumping. However, a recent French study could not support this hypothesis. Other mechanisms, such as a central vagal reflex may play a role in the pathophysiology of suspension syndrome. The aim of this study is to better understand the pathophysiological basis of suspension syndrome and to develop practical recommendations for prevention and treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •Age 18-50 years
- •ASA class 1
- •Signed informed consent
排除标准
- •Age <18 or >50 years
- •ASA class >1
- •Informed consent not signed
研究组 & 干预措施
Suspension without prior climbing
Free Suspension in a harness after baseline measurements and without prior climbing
干预措施: Suspension in a harness (Other)
Suspension with prior climbing
Free Suspension in a harness after baseline measurements and after climbing in moderate intensity for 10 minutes
干预措施: Suspension in a harness (Other)
Suspension with prior climbing
Free Suspension in a harness after baseline measurements and after climbing in moderate intensity for 10 minutes
干预措施: Climbing (Other)
结局指标
主要结局
Blood pressure
时间窗: Change from baseline (measurement at minute 0) -> suspension phase (minute 10, timepoint immediately before interruption of suspension phase [max 60 minutes]) -> minute 5 and minute 15 after suspension phase
Heart rate
时间窗: Change from baseline (measurement at minute 0) -> suspension phase (minute 10, timepoint immediately before interruption of suspension phase [max 60 minutes]) -> minute 5 and minute 15 after suspension phase
次要结局
- Change in interbeat-interval(Change from baseline (measurement at minute 0) -> suspension phase (minute 10, timepoint immediately before interruption of suspension phase [max 60 minutes]) -> minute 5 and minute 15 after suspension phase)
- Change in maximal Diameter of superficial femoral vein(Change from baseline (measurement at minute 0) -> suspension phase (minute 10, timepoint immediately before interruption of suspension phase [max 60 minutes]) -> minute 5 and minute 15 after suspension phase)