CTRI/2023/03/050179进行中（未招募）3 期
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery Trial - DEPOSITIO
试验速览
- 阶段
- 3 期
- 状态
- 进行中（未招募）
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1.= 18 years of age
- •2.Undergoing a cardiac surgical procedure (i.e. isolated coronary artery bypass graft (CABG), isolated single cardiac valve surgery or a combination of both or isolated ascending aorta replacement) with the use of cardiopulmonary bypass (CPB) and median sternotomy.
- •3.Provide written informed consent
排除标准
- •1.Allergy to tranexamic acid
- •2.Undergoing minimally invasive surgery
- •3.Fulfill any of the following transfusion risk factors (A-D):
- •A. Emergency surgery B. History of bleeding disorder C. Inherited thromboembolic or hemorrhagic disease D. Infective endocarditis (active)
- •4.History of previous cardiac surgery
- •5.Estimated glomerular filtration rate <30 mL/min (CKD-EPI equation) or on dialysis
- •6.Pre-operative hemoglobin > 170 g/L or <110 g/L
- •7.Pre-operative thrombocytopenia ( <50,000 platelets per µL)
- •8.Expected circulatory arrest
- •9.Pregnancy or breast feeding
- •10.Previously enrolled in the DEPOSITION trial
- •11.Refusal of blood products
- •12.Pericardiectomy
研究者
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