Probiotics to reduce infections in care home residents

Not Applicable

Completed

• Conditions: Specialty: Infectious diseases and microbiology; Infections and Infestations

• Registration Number: ISRCTN16392920
• Lead Sponsor: Cardiff University

Brief Summary

2019 Protocol article in https://pubmed.ncbi.nlm.nih.gov/31227535/ protocol (added 09/06/2020) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32633801/ results (added 08/07/2020) 2021 Other publications in https://doi.org/10.3389/fragi.2021.599084 Relationships Between Age, Frailty, Length of Care Home Residence and Biomarkers of Immunity and Inflammation in Older Care Home Residents in the United Kingdom (added 06/08/2024) 2021 Results article in https://doi.org/10.3389/fimmu.2021.643321 (added 06/08/2024) 2021 Results article in https://doi.org/10.3310/eme08070 (added 06/08/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2016-07-20
• Study Completion: 2019-07-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 310

Inclusion Criteria

1. Aged 65 years or older
2. Currently living in a care home setting (residential, nursing or mixed)
3. Participant is willing and able to give informed consent for participation in the trial OR if the participant lacks capacity, a consultee is willing to complete a consultee declaration form

Exclusion Criteria

1. Is known to be immunocompromised (requiring immunosuppressants, long term high dose oral, intramuscular or intravenous steroids)
2. Is currently taking regular probiotics and is not willing to adapt to trial protocol
3. Is a temporary care home resident (i.e. less than 1 month of planned transitional/respite residential care)
4. Death is thought to be imminent
5. Lactose intolerant

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Cumulative antibiotic administration days for all cause infections over 12 months<br>2. Total number of days of systemic antibiotic administration as recorded in care home medical records and discharge summaries if the participant is admitted to hospital, over 12 months