Percentage and Spectrum of Iron Deficiency in Systolic Heart Failure Patients in Assiut University Hospital
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- percentage of iron deficiency in systolic heart failure patients
研究概览
简要总结
Heart failure is a common problem with a prevalence of 1-2% in general population and a major cause of mortality,morbidity and impaired quality of life. Anemia is afrequent comorbidity in stable heart failure patients and it increases morbidity in terms of frequent hospital admissions,impaired exercise capacity,poor quality of life ,and increased mortality
详细描述
Iron deficiency with or without anemia has been commonly associated with heart failure .Although iron deficiency is the commonest nutritional deficiency worldwide ,affecting more than one-third of the population,its association with heart failure with or without anemia is of growing interest .As iron supplementation improves prognosis in patients with heart failure ,iron deficiency is an attractive therapeutic target.
In 2012 ,the European society of cardiology Guidelines for the diagnosis and treatment of acute and chronic heart failure recognized iron deficiency as a comorbidity in heart failure for the first time and recommended diagnosis of iron deficiency based on iron parameters in all patients suspected of having heart failure.
Iron deficiency can be classified as absolute or functional. Absolute iron deficiency reflects depleted body stores caused by poor dietary intake, impaired gastrointestinal absorption,and chronic blood loss.
Functional iron deficiency is thought to be caused by increased hepcidin production and subsequent inhibition of the iron exporter ferroportin ,leading to impaired absorption and utilization of iron.
Chronic heart failure patients are susceptible to both forms iron deficiency
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •.100 males or females patients above age of 18years of age and clinically diagnosed with systolic heart failure,ejection fraction<50% by echocardiography admitted in Assiut University hospital
排除标准
- •.Known to be non cardiac condition causing iron deficiency(haemorrhoids,malignancy).
- •.other conditions causing fluid overload(eg.renal failure on dialysis ). .congenital heart disease.
结局指标
主要结局
percentage of iron deficiency in systolic heart failure patients
时间窗: 1 year
systolic heart failure is defined as ejection fraction \<50% absolute iron deficiency is serum ferritin\<100ug/l.Functional iron deficiency is defined as normal serum ferritin(100-300)ug/l with low transferrin saturation\<20%
次要结局
未报告次要终点
研究者
Essam Nan Saleeb
Principal Investigator
Assiut University