Nutritional Management of Post COVID-19 Cognitive Symptoms

Not Applicable

Recruiting

• Conditions: Long COVID
• Interventions: Dietary Supplement: Safflower oil; Dietary Supplement: medium chain triglyceride oil

• Registration Number: NCT05705648
• Lead Sponsor: University of Alberta

Brief Summary

The goal of this clinical trial is to learn about in brain "fog" complaints associated with long-COVID in people aged 22-50-years. The main questions it aims to answer are:

* the natural course of brain "fog" complaints

* the effect, if any of supplemental dietary oil on brain "fog" complaints Participants will be asked to undergo some brain testing (X-rays and questions. Treatments they'll be given will be one of two supplemental oils to consume daily.

Researchers will compare outcomes in the two different oil groups to see if it has any effect on brain "fog" complaints.

Detailed Description

Randomized placebo-control clinical trial comparing two types of nutritional oil and evaluating the impact, if any, on subjective complaints of long-COVID cognitive changes.

Study Timeline

• Study First Submitted: 2023-01-27
• Study First Submitted QC: 2023-01-27
• Study First Posted: 2023-01-31
• Study Start: 2023-10-01
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-07
• Last Update Posted: 2024-10-09
• Primary Completion: 2025-03-30
• Study Completion: 2026-03-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• confirmed COVID infection, at least 3 months previously, with ongoing cognitive complaints
• all other medical conditions stable, and on stable doses of medications (if required)

Exclusion Criteria

• COVID infection not confirmed by PCR or Rapid test
• unable to speak English
• pre-COVID cognitve complaints, and/or medical diagnoses affecting cognitive function

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Safflower oil	Safflower oil 15mls tid x 5 months
Intervention	medium chain triglyceride oil	Medium chain triglyceride oil 15ml tid x 5 months

Primary Outcome Measures

Name	Time	Method
Cognigram(R)	12-months	computer-based cognitive test

Secondary Outcome Measures

Name	Time	Method
Montreal Cognitive Assessment	12-months	Cognitive test

Trial Locations

Locations (1)

University of Alberta; 🇨🇦 Edmonton, Alberta, Canada